The antiplasmid action of some palladium(II) complexes of phenothiazine based pharmaceuticals and the crystal structure of protonated trichloro[10-(3′-dimethylaminopropyl) phenothiazine-S]-palladium(II)

Susan E. Kidd, Trevor W. Hambley, Anikó Hevér, Maree J. Nelson, Joseph Molnár

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Palladium(II) complexes of phenothiazines were synthesized and examined for their antiplasmid activity on E. coli. It was found that the complex of unsubstituted phenothiazine was ineffective; however, the complexes of chlorpromazine and promazine were able to eliminate the F'lac plasmid of E. coli and inhibited intercellular plasmid transfer. The crystal structure of [Pd(pzH)Cl3] (pzH is protonated promazine) has been determined by X-ray diffraction methods and refined to a residual of 0.028 for 2821 independent observed reflections. The crystals are monoclinic, space group P21/n; a 8.166(2); b 26.855(5); c 9.141(2) Å; β 110.65(2)°. Promazine is bonded via an S atom to a PdCl3- unit with the charge being balanced by a protonated amino group.

Original languageEnglish
Pages (from-to)171-181
Number of pages11
JournalJournal of Inorganic Biochemistry
Volume62
Issue number3
DOIs
Publication statusPublished - 15 May 1996

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