The antiplasmid action of some palladium(II) complexes of phenothiazine based pharmaceuticals and the crystal structure of protonated trichloro[10-(3′-dimethylaminopropyl) phenothiazine-S]-palladium(II)

Susan E. Kidd; Trevor W. Hambley; Anikó Hevér; Maree J. Nelson; Joseph Molnár

doi:10.1016/0162-0134(95)00145-X

The antiplasmid action of some palladium(II) complexes of phenothiazine based pharmaceuticals and the crystal structure of protonated trichloro[10-(3′-dimethylaminopropyl) phenothiazine-S]-palladium(II)

Susan E. Kidd, Trevor W. Hambley, Anikó Hevér, Maree J. Nelson, Joseph Molnár

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Palladium(II) complexes of phenothiazines were synthesized and examined for their antiplasmid activity on E. coli. It was found that the complex of unsubstituted phenothiazine was ineffective; however, the complexes of chlorpromazine and promazine were able to eliminate the F'lac plasmid of E. coli and inhibited intercellular plasmid transfer. The crystal structure of [Pd(pzH)Cl₃] (pzH is protonated promazine) has been determined by X-ray diffraction methods and refined to a residual of 0.028 for 2821 independent observed reflections. The crystals are monoclinic, space group P2₁/n; a 8.166(2); b 26.855(5); c 9.141(2) Å; β 110.65(2)°. Promazine is bonded via an S atom to a PdCl₃^- unit with the charge being balanced by a protonated amino group.

Original language	English
Pages (from-to)	171-181
Number of pages	11
Journal	Journal of Inorganic Biochemistry
Volume	62
Issue number	3
DOIs	https://doi.org/10.1016/0162-0134(95)00145-X
Publication status	Published - 15 May 1996

Access to Document

10.1016/0162-0134(95)00145-X

Fingerprint

Dive into the research topics of 'The antiplasmid action of some palladium(II) complexes of phenothiazine based pharmaceuticals and the crystal structure of protonated trichloro[10-(3′-dimethylaminopropyl) phenothiazine-S]-palladium(II)'. Together they form a unique fingerprint.

Cite this

Kidd, S. E., Hambley, T. W., Hevér, A., Nelson, M. J., & Molnár, J. (1996). The antiplasmid action of some palladium(II) complexes of phenothiazine based pharmaceuticals and the crystal structure of protonated trichloro[10-(3′-dimethylaminopropyl) phenothiazine-S]-palladium(II). Journal of Inorganic Biochemistry, 62(3), 171-181. https://doi.org/10.1016/0162-0134(95)00145-X

@article{5627f761a97b4455ac869162c341ac9e,

title = "The antiplasmid action of some palladium(II) complexes of phenothiazine based pharmaceuticals and the crystal structure of protonated trichloro[10-(3′-dimethylaminopropyl) phenothiazine-S]-palladium(II)",

abstract = "Palladium(II) complexes of phenothiazines were synthesized and examined for their antiplasmid activity on E. coli. It was found that the complex of unsubstituted phenothiazine was ineffective; however, the complexes of chlorpromazine and promazine were able to eliminate the F'lac plasmid of E. coli and inhibited intercellular plasmid transfer. The crystal structure of [Pd(pzH)Cl3] (pzH is protonated promazine) has been determined by X-ray diffraction methods and refined to a residual of 0.028 for 2821 independent observed reflections. The crystals are monoclinic, space group P21/n; a 8.166(2); b 26.855(5); c 9.141(2) {\AA}; β 110.65(2)°. Promazine is bonded via an S atom to a PdCl3- unit with the charge being balanced by a protonated amino group.",

author = "Kidd, {Susan E.} and Hambley, {Trevor W.} and Anik{\'o} Hev{\'e}r and Nelson, {Maree J.} and Joseph Moln{\'a}r",

year = "1996",

month = may,

day = "15",

doi = "10.1016/0162-0134(95)00145-X",

language = "English",

volume = "62",

pages = "171--181",

journal = "Journal of Inorganic Biochemistry",

issn = "0162-0134",

publisher = "Elsevier",

number = "3",

}

Kidd, SE, Hambley, TW, Hevér, A, Nelson, MJ & Molnár, J 1996, 'The antiplasmid action of some palladium(II) complexes of phenothiazine based pharmaceuticals and the crystal structure of protonated trichloro[10-(3′-dimethylaminopropyl) phenothiazine-S]-palladium(II)', Journal of Inorganic Biochemistry, vol. 62, no. 3, pp. 171-181. https://doi.org/10.1016/0162-0134(95)00145-X

The antiplasmid action of some palladium(II) complexes of phenothiazine based pharmaceuticals and the crystal structure of protonated trichloro[10-(3′-dimethylaminopropyl) phenothiazine-S]-palladium(II). / Kidd, Susan E.; Hambley, Trevor W.; Hevér, Anikó et al.
In: Journal of Inorganic Biochemistry, Vol. 62, No. 3, 15.05.1996, p. 171-181.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The antiplasmid action of some palladium(II) complexes of phenothiazine based pharmaceuticals and the crystal structure of protonated trichloro[10-(3′-dimethylaminopropyl) phenothiazine-S]-palladium(II)

AU - Kidd, Susan E.

AU - Hambley, Trevor W.

AU - Hevér, Anikó

AU - Nelson, Maree J.

AU - Molnár, Joseph

PY - 1996/5/15

Y1 - 1996/5/15

N2 - Palladium(II) complexes of phenothiazines were synthesized and examined for their antiplasmid activity on E. coli. It was found that the complex of unsubstituted phenothiazine was ineffective; however, the complexes of chlorpromazine and promazine were able to eliminate the F'lac plasmid of E. coli and inhibited intercellular plasmid transfer. The crystal structure of [Pd(pzH)Cl3] (pzH is protonated promazine) has been determined by X-ray diffraction methods and refined to a residual of 0.028 for 2821 independent observed reflections. The crystals are monoclinic, space group P21/n; a 8.166(2); b 26.855(5); c 9.141(2) Å; β 110.65(2)°. Promazine is bonded via an S atom to a PdCl3- unit with the charge being balanced by a protonated amino group.

AB - Palladium(II) complexes of phenothiazines were synthesized and examined for their antiplasmid activity on E. coli. It was found that the complex of unsubstituted phenothiazine was ineffective; however, the complexes of chlorpromazine and promazine were able to eliminate the F'lac plasmid of E. coli and inhibited intercellular plasmid transfer. The crystal structure of [Pd(pzH)Cl3] (pzH is protonated promazine) has been determined by X-ray diffraction methods and refined to a residual of 0.028 for 2821 independent observed reflections. The crystals are monoclinic, space group P21/n; a 8.166(2); b 26.855(5); c 9.141(2) Å; β 110.65(2)°. Promazine is bonded via an S atom to a PdCl3- unit with the charge being balanced by a protonated amino group.

UR - http://www.scopus.com/inward/record.url?scp=0029872146&partnerID=8YFLogxK

U2 - 10.1016/0162-0134(95)00145-X

DO - 10.1016/0162-0134(95)00145-X

M3 - Article

AN - SCOPUS:0029872146

SN - 0162-0134

VL - 62

SP - 171

EP - 181

JO - Journal of Inorganic Biochemistry

JF - Journal of Inorganic Biochemistry

IS - 3

ER -

The antiplasmid action of some palladium(II) complexes of phenothiazine based pharmaceuticals and the crystal structure of protonated trichloro[10-(3′-dimethylaminopropyl) phenothiazine-S]-palladium(II)

Abstract

Access to Document

Other files and links

Fingerprint

Cite this