The ARF tumour suppressor

Stuart J. Gallagher; Richard F. Kefford; Helen Rizos

doi:10.1016/j.biocel.2006.02.008

The ARF tumour suppressor

Stuart J. Gallagher, Richard F. Kefford, Helen Rizos^*

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

74 Citations (Scopus)

Abstract

The ARF tumour suppressor is a product of the INK4a/ARF locus; a sequence that is frequently altered in human cancer. ARF is upregulated by oncogenic stimuli and is a critical regulator of p53 stability through interactions with the mdm2 and ARF-BP1/Mule ubiquitin ligases. Cellular stress signals liberate ARF from the nucleolus where it is bound to B23/nucleophosmin. This nucleolar location of ARF may serve as a reservoir for the rapid induction of p53, but may also serve to co-ordinate effects on cell cycle, survival and growth. The biological functions of ARF interactions with other binding partners remain uncertain, but ARF-mediated sumoylation may represent a unifying effector pathway.

Original language	English
Pages (from-to)	1637-1641
Number of pages	5
Journal	International Journal of Biochemistry and Cell Biology
Volume	38
Issue number	10
DOIs	https://doi.org/10.1016/j.biocel.2006.02.008
Publication status	Published - 2006
Externally published	Yes

Keywords

INK4a/ARF
Melanoma
Nucleolus
p53 pathway
Senescence
SUMO

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10.1016/j.biocel.2006.02.008

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title = "The ARF tumour suppressor",

abstract = "The ARF tumour suppressor is a product of the INK4a/ARF locus; a sequence that is frequently altered in human cancer. ARF is upregulated by oncogenic stimuli and is a critical regulator of p53 stability through interactions with the mdm2 and ARF-BP1/Mule ubiquitin ligases. Cellular stress signals liberate ARF from the nucleolus where it is bound to B23/nucleophosmin. This nucleolar location of ARF may serve as a reservoir for the rapid induction of p53, but may also serve to co-ordinate effects on cell cycle, survival and growth. The biological functions of ARF interactions with other binding partners remain uncertain, but ARF-mediated sumoylation may represent a unifying effector pathway.",

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author = "Gallagher, {Stuart J.} and Kefford, {Richard F.} and Helen Rizos",

year = "2006",

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volume = "38",

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journal = "International Journal of Biochemistry and Cell Biology",

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TY - JOUR

T1 - The ARF tumour suppressor

AU - Gallagher, Stuart J.

AU - Kefford, Richard F.

AU - Rizos, Helen

PY - 2006

Y1 - 2006

N2 - The ARF tumour suppressor is a product of the INK4a/ARF locus; a sequence that is frequently altered in human cancer. ARF is upregulated by oncogenic stimuli and is a critical regulator of p53 stability through interactions with the mdm2 and ARF-BP1/Mule ubiquitin ligases. Cellular stress signals liberate ARF from the nucleolus where it is bound to B23/nucleophosmin. This nucleolar location of ARF may serve as a reservoir for the rapid induction of p53, but may also serve to co-ordinate effects on cell cycle, survival and growth. The biological functions of ARF interactions with other binding partners remain uncertain, but ARF-mediated sumoylation may represent a unifying effector pathway.

AB - The ARF tumour suppressor is a product of the INK4a/ARF locus; a sequence that is frequently altered in human cancer. ARF is upregulated by oncogenic stimuli and is a critical regulator of p53 stability through interactions with the mdm2 and ARF-BP1/Mule ubiquitin ligases. Cellular stress signals liberate ARF from the nucleolus where it is bound to B23/nucleophosmin. This nucleolar location of ARF may serve as a reservoir for the rapid induction of p53, but may also serve to co-ordinate effects on cell cycle, survival and growth. The biological functions of ARF interactions with other binding partners remain uncertain, but ARF-mediated sumoylation may represent a unifying effector pathway.

KW - INK4a/ARF

KW - Melanoma

KW - Nucleolus

KW - p53 pathway

KW - Senescence

KW - SUMO

UR - http://www.scopus.com/inward/record.url?scp=33745403859&partnerID=8YFLogxK

U2 - 10.1016/j.biocel.2006.02.008

DO - 10.1016/j.biocel.2006.02.008

M3 - Short survey

C2 - 16600663

AN - SCOPUS:33745403859

VL - 38

SP - 1637

EP - 1641

JO - International Journal of Biochemistry and Cell Biology

JF - International Journal of Biochemistry and Cell Biology

SN - 1357-2725

IS - 10

ER -

The ARF tumour suppressor

Abstract

Keywords

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