The ARF tumour suppressor

Stuart J. Gallagher, Richard F. Kefford, Helen Rizos*

*Corresponding author for this work

Research output: Contribution to journalShort survey

68 Citations (Scopus)

Abstract

The ARF tumour suppressor is a product of the INK4a/ARF locus; a sequence that is frequently altered in human cancer. ARF is upregulated by oncogenic stimuli and is a critical regulator of p53 stability through interactions with the mdm2 and ARF-BP1/Mule ubiquitin ligases. Cellular stress signals liberate ARF from the nucleolus where it is bound to B23/nucleophosmin. This nucleolar location of ARF may serve as a reservoir for the rapid induction of p53, but may also serve to co-ordinate effects on cell cycle, survival and growth. The biological functions of ARF interactions with other binding partners remain uncertain, but ARF-mediated sumoylation may represent a unifying effector pathway.

Original languageEnglish
Pages (from-to)1637-1641
Number of pages5
JournalInternational Journal of Biochemistry and Cell Biology
Volume38
Issue number10
DOIs
Publication statusPublished - 2006
Externally publishedYes

Keywords

  • INK4a/ARF
  • Melanoma
  • Nucleolus
  • p53 pathway
  • Senescence
  • SUMO

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