The assembly of a photoluminescent nanocomplex based on upconversion nanoparticles

S. Shanwar, L. Liang, A. V. Nechaev, I. V. Balalaeva, V. A. Vodeneev, A. V. Zvyagin, E. L. Guryev

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1 Citation (Scopus)
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Over the past two decades, developments in the field of nanobiomedicine have come a long way despite the unresolved hindrances. The creation and development of effective theranostic agents based on nanomaterials are urgent needs of modern medicine. Upconversion nanoparticles (UCNP) appear to be the most promising agents for developing theranostics due to their unique optical properties. There has been extensive research on new approaches to obtain stable colloids capable of prolonged circulation in the bloodstream, particularly with bovine serum albumin (BSA). The present work contributes to solving the problem of obtaining stable agents based on UCNP by coating water-soluble UCNP-NOBF4 with a stable protein corona layer of BSA. The assembled nanocomplex is promising for usage as a diagnostic agent and is set for further investigation.

Original languageEnglish
Pages (from-to)42-48
Number of pages7
JournalOpera Medica et Physiologica
Issue number4
Publication statusPublished - Dec 2020

Bibliographical note

Copyright © 2020, Lobachevsky State University of Nizhny Novgorod. All rights reserved. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.


  • Bovine serum albumin
  • Protein corona
  • Upconversion nanoparticle


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