TY - JOUR
T1 - The association between Alzheimer's disease related markers and physical activity in cognitively normal older adults
AU - Pedrini, Steve
AU - Chatterjee, Pratishtha
AU - Nakamura, Akinori
AU - Tegg, Michelle
AU - Hone, Eugene
AU - Rainey-Smith, Stephanie R.
AU - Rowe, Christopher C.
AU - Dore, Vincent
AU - Villemagne, Victor L.
AU - Ames, David
AU - Kaneko, Naoki
AU - Gardener, Sam L.
AU - Taddei, Kevin
AU - Fernando, Binosha
AU - Martins, Ian
AU - Bharadwaj, Prashant
AU - Sohrabi, Hamid R.
AU - Masters, Colin L.
AU - Brown, Belinda
AU - Martins, Ralph N.
AU - The AIBL Research Group
N1 - Copyright the Author(s) 2022. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.
PY - 2022/3/28
Y1 - 2022/3/28
N2 - Previous studies have indicated that physical activity may be beneficial in reducing the risk for Alzheimer's disease (AD), although the underlying mechanisms are not fully understood. The goal of this study was to evaluate the relationship between habitual physical activity levels and brain amyloid deposition and AD-related blood biomarkers (i.e., measured using a novel high-performance mass spectrometry-based assay), in apolipoprotein E (APOE) ε4 carriers and noncarriers. We evaluated 143 cognitively normal older adults, all of whom had brain amyloid deposition assessed using positron emission tomography and had their physical activity levels measured using the International Physical Activity Questionnaire (IPAQ). We observed an inverse correlation between brain amyloidosis and plasma beta-amyloid (Aβ)
1−42 but found no association between brain amyloid and plasma Aβ
1−40 and amyloid precursor protein (APP)
669−711. Additionally, higher levels of physical activity were associated with lower plasma Aβ
1−40, Aβ
1−42, and APP
669−711 levels in APOE ε4 noncarriers. The ratios of Aβ
1−40/Aβ
1−42 and APP
669−711/Aβ
1−42, which have been associated with higher brain amyloidosis in previous studies, differed between APOE ε4 carriers and non-carriers. Taken together, these data indicate a complex relationship between physical activity and brain amyloid deposition and potential blood-based AD biomarkers in cognitively normal older adults. In addition, the role of APOE ε4 is still unclear, and more studies are necessary to bring further clarification.
AB - Previous studies have indicated that physical activity may be beneficial in reducing the risk for Alzheimer's disease (AD), although the underlying mechanisms are not fully understood. The goal of this study was to evaluate the relationship between habitual physical activity levels and brain amyloid deposition and AD-related blood biomarkers (i.e., measured using a novel high-performance mass spectrometry-based assay), in apolipoprotein E (APOE) ε4 carriers and noncarriers. We evaluated 143 cognitively normal older adults, all of whom had brain amyloid deposition assessed using positron emission tomography and had their physical activity levels measured using the International Physical Activity Questionnaire (IPAQ). We observed an inverse correlation between brain amyloidosis and plasma beta-amyloid (Aβ)
1−42 but found no association between brain amyloid and plasma Aβ
1−40 and amyloid precursor protein (APP)
669−711. Additionally, higher levels of physical activity were associated with lower plasma Aβ
1−40, Aβ
1−42, and APP
669−711 levels in APOE ε4 noncarriers. The ratios of Aβ
1−40/Aβ
1−42 and APP
669−711/Aβ
1−42, which have been associated with higher brain amyloidosis in previous studies, differed between APOE ε4 carriers and non-carriers. Taken together, these data indicate a complex relationship between physical activity and brain amyloid deposition and potential blood-based AD biomarkers in cognitively normal older adults. In addition, the role of APOE ε4 is still unclear, and more studies are necessary to bring further clarification.
KW - APOE genotype
KW - Alzheimer's disease
KW - amyloid
KW - biomarkers
KW - physical activity
UR - http://www.scopus.com/inward/record.url?scp=85133567942&partnerID=8YFLogxK
U2 - 10.3389/fnagi.2022.771214
DO - 10.3389/fnagi.2022.771214
M3 - Article
C2 - 35418852
AN - SCOPUS:85133567942
SN - 1663-4365
VL - 14
SP - 1
EP - 9
JO - Frontiers in Aging Neuroscience
JF - Frontiers in Aging Neuroscience
M1 - 771214
ER -