The association between chronic arsenic exposure and type 2 diabetes: a meta-analysis

Bayzidur Rahman; Tanvir Abir; A. K. M. Akbar Hossain; Md Rafiqul Islam; Abul Hasnat Milton

doi:10.1016/B978-0-12-418688-0.00024-1

The association between chronic arsenic exposure and type 2 diabetes: a meta-analysis

Bayzidur Rahman^*, Tanvir Abir, A. K. M. Akbar Hossain, Md Rafiqul Islam, Abul Hasnat Milton

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

An association has been reported between chronic arsenic exposure and type 2 diabetes (T2D), although the evidence is still inconclusive. We incorporated 27 studies in the analysis including 15 cross-sectional, four case-control, and three cohort studies reporting OR, and three cross-sectional and two cohort studies reporting RR. The pooled OR estimate was 1.58 (95% CI: 1.35, 1.84), and the pooled RR was 1.28 (95% CI: 1.03, 1.59). The overall pooled estimate was 1.50 (95% CI: 1.33, 1.69). The between-study heterogeneity was high (I²=75.5%). We did not observe any significant dose-response association and there was no evidence of publication bias in this study.Overall, this meta-analysis suggests that chronic arsenic exposure is likely to increase the risk of T2D. However, this finding is limited by high between-study heterogeneity. Therefore, the hypothesized association needs further validation through well-conducted large prospective cohort studies with better exposure assessment.

Original language	English
Title of host publication	Handbook of arsenic toxicology
Editors	S. J. S. Flora
Place of Publication	Amsterdam
Publisher	Elsevier Academic Press
Chapter	24
Pages	557-573
Number of pages	17
ISBN (Electronic)	9780124199552
ISBN (Print)	9780124186880
DOIs	https://doi.org/10.1016/B978-0-12-418688-0.00024-1
Publication status	Published - 8 Jan 2015
Externally published	Yes

Keywords

Arsenic
Diabetes mellitus
Drinking water
Meta-analysis
Type 2 diabetes

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10.1016/B978-0-12-418688-0.00024-1

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title = "The association between chronic arsenic exposure and type 2 diabetes: a meta-analysis",

abstract = "An association has been reported between chronic arsenic exposure and type 2 diabetes (T2D), although the evidence is still inconclusive. We incorporated 27 studies in the analysis including 15 cross-sectional, four case-control, and three cohort studies reporting OR, and three cross-sectional and two cohort studies reporting RR. The pooled OR estimate was 1.58 (95% CI: 1.35, 1.84), and the pooled RR was 1.28 (95% CI: 1.03, 1.59). The overall pooled estimate was 1.50 (95% CI: 1.33, 1.69). The between-study heterogeneity was high (I2=75.5%). We did not observe any significant dose-response association and there was no evidence of publication bias in this study.Overall, this meta-analysis suggests that chronic arsenic exposure is likely to increase the risk of T2D. However, this finding is limited by high between-study heterogeneity. Therefore, the hypothesized association needs further validation through well-conducted large prospective cohort studies with better exposure assessment.",

keywords = "Arsenic, Diabetes mellitus, Drinking water, Meta-analysis, Type 2 diabetes",

author = "Bayzidur Rahman and Tanvir Abir and {Akbar Hossain}, {A. K. M.} and Islam, {Md Rafiqul} and Milton, {Abul Hasnat}",

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T1 - The association between chronic arsenic exposure and type 2 diabetes

T2 - a meta-analysis

AU - Rahman, Bayzidur

AU - Abir, Tanvir

AU - Akbar Hossain, A. K. M.

AU - Islam, Md Rafiqul

AU - Milton, Abul Hasnat

PY - 2015/1/8

Y1 - 2015/1/8

N2 - An association has been reported between chronic arsenic exposure and type 2 diabetes (T2D), although the evidence is still inconclusive. We incorporated 27 studies in the analysis including 15 cross-sectional, four case-control, and three cohort studies reporting OR, and three cross-sectional and two cohort studies reporting RR. The pooled OR estimate was 1.58 (95% CI: 1.35, 1.84), and the pooled RR was 1.28 (95% CI: 1.03, 1.59). The overall pooled estimate was 1.50 (95% CI: 1.33, 1.69). The between-study heterogeneity was high (I2=75.5%). We did not observe any significant dose-response association and there was no evidence of publication bias in this study.Overall, this meta-analysis suggests that chronic arsenic exposure is likely to increase the risk of T2D. However, this finding is limited by high between-study heterogeneity. Therefore, the hypothesized association needs further validation through well-conducted large prospective cohort studies with better exposure assessment.

AB - An association has been reported between chronic arsenic exposure and type 2 diabetes (T2D), although the evidence is still inconclusive. We incorporated 27 studies in the analysis including 15 cross-sectional, four case-control, and three cohort studies reporting OR, and three cross-sectional and two cohort studies reporting RR. The pooled OR estimate was 1.58 (95% CI: 1.35, 1.84), and the pooled RR was 1.28 (95% CI: 1.03, 1.59). The overall pooled estimate was 1.50 (95% CI: 1.33, 1.69). The between-study heterogeneity was high (I2=75.5%). We did not observe any significant dose-response association and there was no evidence of publication bias in this study.Overall, this meta-analysis suggests that chronic arsenic exposure is likely to increase the risk of T2D. However, this finding is limited by high between-study heterogeneity. Therefore, the hypothesized association needs further validation through well-conducted large prospective cohort studies with better exposure assessment.

KW - Arsenic

KW - Diabetes mellitus

KW - Drinking water

KW - Meta-analysis

KW - Type 2 diabetes

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SN - 9780124186880

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BT - Handbook of arsenic toxicology

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PB - Elsevier Academic Press

CY - Amsterdam

ER -

The association between chronic arsenic exposure and type 2 diabetes: a meta-analysis

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Keywords

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