The association between chronic arsenic exposure and type 2 diabetes: a meta-analysis

Bayzidur Rahman*, Tanvir Abir, A. K. M. Akbar Hossain, Md Rafiqul Islam, Abul Hasnat Milton

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


An association has been reported between chronic arsenic exposure and type 2 diabetes (T2D), although the evidence is still inconclusive. We incorporated 27 studies in the analysis including 15 cross-sectional, four case-control, and three cohort studies reporting OR, and three cross-sectional and two cohort studies reporting RR. The pooled OR estimate was 1.58 (95% CI: 1.35, 1.84), and the pooled RR was 1.28 (95% CI: 1.03, 1.59). The overall pooled estimate was 1.50 (95% CI: 1.33, 1.69). The between-study heterogeneity was high (I2=75.5%). We did not observe any significant dose-response association and there was no evidence of publication bias in this study.Overall, this meta-analysis suggests that chronic arsenic exposure is likely to increase the risk of T2D. However, this finding is limited by high between-study heterogeneity. Therefore, the hypothesized association needs further validation through well-conducted large prospective cohort studies with better exposure assessment.

Original languageEnglish
Title of host publicationHandbook of arsenic toxicology
EditorsS. J. S. Flora
Place of PublicationAmsterdam
PublisherElsevier Academic Press
Number of pages17
ISBN (Electronic)9780124199552
ISBN (Print)9780124186880
Publication statusPublished - 8 Jan 2015
Externally publishedYes


  • Arsenic
  • Diabetes mellitus
  • Drinking water
  • Meta-analysis
  • Type 2 diabetes


Dive into the research topics of 'The association between chronic arsenic exposure and type 2 diabetes: a meta-analysis'. Together they form a unique fingerprint.

Cite this