The association between chronic arsenic exposure and type 2 diabetes: a metaanalysis

Bayzidur Rahman, Tanvir Abir, A. K. M. Akbar Hossain, Md. Rafiqul Islam, Abul Hasnat Milton

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

An association has been reported between chronic arsenic exposure and type 2 diabetes (T2D), although the evidence is still inconclusive. We incorporated 27 studies in the analysis including 15 cross-sectional, four case-control, and three cohort studies reporting OR, and three cross-sectional and two cohort studies reporting RR. The pooled OR estimate was 1.58 (95% CI: 1.35, 1.84), and the pooled RR was 1.28 (95% CI: 1.03, 1.59). The overall pooled estimate was 1.50 (95% CI: 1.33, 1.69). The between-study heterogeneity was high (I 2 = 75.5%). We did not observe any significant dose-response association and there was no evidence of publication bias in this study. Overall, this metaanalysis suggests that chronic arsenic exposure is likely to increase the risk of T2D. However, this finding is limited by high between-study heterogeneity. Therefore, the hypothesized association needs further validation through well-conducted large prospective cohort studies with better exposure assessment.

Original languageEnglish
Title of host publicationHandbook of arsenic toxicology
EditorsSwaran Jeet Singh Flora
Place of PublicationUnited Kingdom
PublisherElsevier
Chapter24
Pages631-648
Number of pages18
EditionSecond
ISBN (Electronic)9780323898478
ISBN (Print)9780323984713
DOIs
Publication statusPublished - 1 Jan 2023
Externally publishedYes

Keywords

  • Arsenic
  • Diabetes mellitus
  • Drinking water
  • Metaanalysis
  • Type 2 diabetes

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