TY - JOUR
T1 - The association between new generation oral contraceptive pill and the development of inflammatory bowel diseases
AU - Sanagapalli, Santosh
AU - Ko, Yanna
AU - Kariyawasam, Viraj
AU - Ng, Siew C.
AU - Tang, Whitney
AU - Silva, Hithanadura Janaka de
AU - Chen, Minhu
AU - Wu, Kaichun
AU - Aniwan, Satimai
AU - Ng, Ka Kei
AU - Ong, David
AU - Ouyang, Qin
AU - Hilmi, Ida
AU - Simadibrata, Marcellus
AU - Pisespongsa, Pises
AU - Gopikrishna, Saranya
AU - Leong, Rupert W.
AU - Sydney IBD Cohort Collaborators
AU - Asia-Pacific Crohn's and Colitis Epidemiologic Study (ACCESS) Study Group
N1 - Copyright the Publisher 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Background/Aims: To examine the association between use of oral contraceptive pills (OCPs) and the risk of developing inflammatory bowel diseases (IBD), in a modern cohort. Methods: A prospective nested case-control study across sites in the Asia-Pacific region was conducted; involving female IBD cases and asymptomatic controls. Subjects completed a questionnaire addressing questions related to OCP use. Primary outcome was the risk of development of IBD of those exposed to OCP versus non-exposure. Secondary outcomes were development of Crohn's disease (CD) versus ulcerative colitis (UC), and whether age of first use of OCP use may be associated with risk of IBD. Results: Three hundred and forty-eight female IBD cases (41% CD, median age: 43 years) and 590 female age-matched controls were recruited. No significant association was found between OCP use and the risk of IBD (odds ratio [OR], 1.65; 95% confidence interval, 0.77-3.13; P=0.22), CD (OR, 1.55) or UC (OR, 1.01). The lack of association persisted when results were adjusted for age and smoking. IBD cases commenced OCP use at a younger age than controls (18 years vs. 20 years, P=0.049). Conclusions: In this large cohort of subjects from the Asia-Pacific region, we found a modest but not significantly increased risk of developing IBD amongst OCP users.
AB - Background/Aims: To examine the association between use of oral contraceptive pills (OCPs) and the risk of developing inflammatory bowel diseases (IBD), in a modern cohort. Methods: A prospective nested case-control study across sites in the Asia-Pacific region was conducted; involving female IBD cases and asymptomatic controls. Subjects completed a questionnaire addressing questions related to OCP use. Primary outcome was the risk of development of IBD of those exposed to OCP versus non-exposure. Secondary outcomes were development of Crohn's disease (CD) versus ulcerative colitis (UC), and whether age of first use of OCP use may be associated with risk of IBD. Results: Three hundred and forty-eight female IBD cases (41% CD, median age: 43 years) and 590 female age-matched controls were recruited. No significant association was found between OCP use and the risk of IBD (odds ratio [OR], 1.65; 95% confidence interval, 0.77-3.13; P=0.22), CD (OR, 1.55) or UC (OR, 1.01). The lack of association persisted when results were adjusted for age and smoking. IBD cases commenced OCP use at a younger age than controls (18 years vs. 20 years, P=0.049). Conclusions: In this large cohort of subjects from the Asia-Pacific region, we found a modest but not significantly increased risk of developing IBD amongst OCP users.
KW - Contraceptives,oral
KW - Inflammatory bowel diseases
UR - http://www.scopus.com/inward/record.url?scp=85082366390&partnerID=8YFLogxK
U2 - 10.5217/ir.2018.16.3.409
DO - 10.5217/ir.2018.16.3.409
M3 - Article
C2 - 30090040
AN - SCOPUS:85082366390
VL - 16
SP - 409
EP - 415
JO - Intestinal Research
JF - Intestinal Research
SN - 1598-9100
IS - 3
ER -