The association of Aβ amyloid and composite cognitive measures in healthy older adults and MCI

Karra D. Harrington; Yen Ying Lim; Kathryn A. Ellis; Carly Copolov; David Darby; Michael Weinborn; David Ames; Ralph N. Martins; Greg Savage; Cassandra Szoeke; Christopher Rowe; Victor L. Villemagne; Colin L. Masters; Paul Maruff

doi:10.1017/S1041610213001087

The association of Aβ amyloid and composite cognitive measures in healthy older adults and MCI

Karra D. Harrington^*, Yen Ying Lim, Kathryn A. Ellis, Carly Copolov, David Darby, Michael Weinborn, David Ames, Ralph N. Martins, Greg Savage, Cassandra Szoeke, Christopher Rowe, Victor L. Villemagne, Colin L. Masters, Paul Maruff

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Background: To date evidence of the relationship between cognition and Aβ amyloid during the early stages of Alzheimer's Disease (AD) has been inconsistent. This study aimed to describe the nature and magnitude of the relationship between Aβ amyloid and cognitive performance of individuals without dementia. Methods: Composite cognitive measures were developed from the Australian Imaging Biomarkers and Lifestyle study neuropsychological test battery using data from 768 healthy older adults and 133 adults with mild cognitive impairment (MCI). A subgroup of this sample (174 healthy, 53 MCI) underwent neuroimaging for Aβ amyloid. Results: Within the MCI group individuals with high Aβ amyloid showed selective impairment for memory compared with those with low Aβ amyloid; however, this difference was not evident in the healthy group. Conclusions: The current findings provide further evidence of the relationship between Aβ amyloid and cognition, with memory impairment being the primary symptom of the underlying disease during the prodromal phases of AD.

Original language	English
Pages (from-to)	1667-1677
Number of pages	11
Journal	International Psychogeriatrics
Volume	25
Issue number	10
DOIs	https://doi.org/10.1017/S1041610213001087
Publication status	Published - Oct 2013

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Harrington, K. D., Lim, Y. Y., Ellis, K. A., Copolov, C., Darby, D., Weinborn, M., Ames, D., Martins, R. N., Savage, G., Szoeke, C., Rowe, C., Villemagne, V. L., Masters, C. L., & Maruff, P. (2013). The association of Aβ amyloid and composite cognitive measures in healthy older adults and MCI. International Psychogeriatrics, 25(10), 1667-1677. https://doi.org/10.1017/S1041610213001087

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title = "The association of Aβ amyloid and composite cognitive measures in healthy older adults and MCI",

abstract = "Background: To date evidence of the relationship between cognition and Aβ amyloid during the early stages of Alzheimer's Disease (AD) has been inconsistent. This study aimed to describe the nature and magnitude of the relationship between Aβ amyloid and cognitive performance of individuals without dementia. Methods: Composite cognitive measures were developed from the Australian Imaging Biomarkers and Lifestyle study neuropsychological test battery using data from 768 healthy older adults and 133 adults with mild cognitive impairment (MCI). A subgroup of this sample (174 healthy, 53 MCI) underwent neuroimaging for Aβ amyloid. Results: Within the MCI group individuals with high Aβ amyloid showed selective impairment for memory compared with those with low Aβ amyloid; however, this difference was not evident in the healthy group. Conclusions: The current findings provide further evidence of the relationship between Aβ amyloid and cognition, with memory impairment being the primary symptom of the underlying disease during the prodromal phases of AD.",

author = "Harrington, {Karra D.} and Lim, {Yen Ying} and Ellis, {Kathryn A.} and Carly Copolov and David Darby and Michael Weinborn and David Ames and Martins, {Ralph N.} and Greg Savage and Cassandra Szoeke and Christopher Rowe and Villemagne, {Victor L.} and Masters, {Colin L.} and Paul Maruff",

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Harrington, KD, Lim, YY, Ellis, KA, Copolov, C, Darby, D, Weinborn, M, Ames, D, Martins, RN , Savage, G, Szoeke, C, Rowe, C, Villemagne, VL, Masters, CL & Maruff, P 2013, 'The association of Aβ amyloid and composite cognitive measures in healthy older adults and MCI', International Psychogeriatrics, vol. 25, no. 10, pp. 1667-1677. https://doi.org/10.1017/S1041610213001087

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AU - Lim, Yen Ying

AU - Ellis, Kathryn A.

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AU - Darby, David

AU - Weinborn, Michael

AU - Ames, David

AU - Martins, Ralph N.

AU - Savage, Greg

AU - Szoeke, Cassandra

AU - Rowe, Christopher

AU - Villemagne, Victor L.

AU - Masters, Colin L.

AU - Maruff, Paul

PY - 2013/10

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N2 - Background: To date evidence of the relationship between cognition and Aβ amyloid during the early stages of Alzheimer's Disease (AD) has been inconsistent. This study aimed to describe the nature and magnitude of the relationship between Aβ amyloid and cognitive performance of individuals without dementia. Methods: Composite cognitive measures were developed from the Australian Imaging Biomarkers and Lifestyle study neuropsychological test battery using data from 768 healthy older adults and 133 adults with mild cognitive impairment (MCI). A subgroup of this sample (174 healthy, 53 MCI) underwent neuroimaging for Aβ amyloid. Results: Within the MCI group individuals with high Aβ amyloid showed selective impairment for memory compared with those with low Aβ amyloid; however, this difference was not evident in the healthy group. Conclusions: The current findings provide further evidence of the relationship between Aβ amyloid and cognition, with memory impairment being the primary symptom of the underlying disease during the prodromal phases of AD.

AB - Background: To date evidence of the relationship between cognition and Aβ amyloid during the early stages of Alzheimer's Disease (AD) has been inconsistent. This study aimed to describe the nature and magnitude of the relationship between Aβ amyloid and cognitive performance of individuals without dementia. Methods: Composite cognitive measures were developed from the Australian Imaging Biomarkers and Lifestyle study neuropsychological test battery using data from 768 healthy older adults and 133 adults with mild cognitive impairment (MCI). A subgroup of this sample (174 healthy, 53 MCI) underwent neuroimaging for Aβ amyloid. Results: Within the MCI group individuals with high Aβ amyloid showed selective impairment for memory compared with those with low Aβ amyloid; however, this difference was not evident in the healthy group. Conclusions: The current findings provide further evidence of the relationship between Aβ amyloid and cognition, with memory impairment being the primary symptom of the underlying disease during the prodromal phases of AD.

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The association of Aβ amyloid and composite cognitive measures in healthy older adults and MCI

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