TY - JOUR
T1 - The biological mechanisms of PCNA and BMP in TMJ adaptive remodeling
AU - Barnouti, Zoe Potres
AU - Owtad, Payam
AU - Shen, Gang
AU - Petocz, Peter
AU - Darendeliler, M. Ali
PY - 2011/1
Y1 - 2011/1
N2 - Objectives: To histologically and immunohistochemically assess the pattern of expression of bone morphogenic proteins 2 and 4 (BMP2/4) and proliferating cell nuclear antigen (PCNA) in response to bite jumping appliances in the condylar cartilage and the glenoid fossa. Materials and Methods: Fifty-five 4-week-old female Sprague-Dawley rats were randomly divided into four experimental and four control groups. Bite-jumping appliances were fitted to the experimental animals. The rats were sacrificed at 3, 14, 21, and 30 days, and the temporomandibular structures were analyzed histologically and immunohistochemically. Results: The expression of BMP2/4 in response to bite-jumping appliances was statistically significant in the condylar cartilage and the glenoid fossa. Cell proliferation was not significant. Conclusion: BMP2/4 plays an important role in bone formation in response to mandibular advancement by accelerating and enhancing the differentiation of mesenchymal cells into boneforming cells.
AB - Objectives: To histologically and immunohistochemically assess the pattern of expression of bone morphogenic proteins 2 and 4 (BMP2/4) and proliferating cell nuclear antigen (PCNA) in response to bite jumping appliances in the condylar cartilage and the glenoid fossa. Materials and Methods: Fifty-five 4-week-old female Sprague-Dawley rats were randomly divided into four experimental and four control groups. Bite-jumping appliances were fitted to the experimental animals. The rats were sacrificed at 3, 14, 21, and 30 days, and the temporomandibular structures were analyzed histologically and immunohistochemically. Results: The expression of BMP2/4 in response to bite-jumping appliances was statistically significant in the condylar cartilage and the glenoid fossa. Cell proliferation was not significant. Conclusion: BMP2/4 plays an important role in bone formation in response to mandibular advancement by accelerating and enhancing the differentiation of mesenchymal cells into boneforming cells.
UR - http://www.scopus.com/inward/record.url?scp=78649582225&partnerID=8YFLogxK
U2 - 10.2319/091609-522.1
DO - 10.2319/091609-522.1
M3 - Article
C2 - 20936960
AN - SCOPUS:79952200987
VL - 81
SP - 91
EP - 99
JO - The Angle orthodontist
JF - The Angle orthodontist
SN - 0003-3219
IS - 1
M1 - 091609-522.1
ER -