The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts

Ian T. Paulsen; Rekha Seshadri; Karen E. Nelson; Jonathan A. Eisen; John F. Heidelberg; Timothy D. Read; Robert J. Dodson; Lowell Umayam; Lauren M. Brinkac; Maureen J. Beanan; Sean C. Daugherty; Robert T. Deboy; A. Scott Durkin; James F. Kolonay; Ramana Madupu; William C. Nelson; Bola Ayodeji; Margaret Kraul; Jyoti Shetty; Joel Malek; Susan E. Van Aken; Steven Riedmuller; Herve Tettelin; Steven R. Gill; Owen White; Steven L. Salzberg; David L. Hoover; Luther E. Lindler; Shirley M. Halling; Stephen M. Boyle; Claire M. Fraser

doi:10.1073/pnas.192319099

The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts

Ian T. Paulsen^*, Rekha Seshadri, Karen E. Nelson, Jonathan A. Eisen, John F. Heidelberg, Timothy D. Read, Robert J. Dodson, Lowell Umayam, Lauren M. Brinkac, Maureen J. Beanan, Sean C. Daugherty, Robert T. Deboy, A. Scott Durkin, James F. Kolonay, Ramana Madupu, William C. Nelson, Bola Ayodeji, Margaret Kraul, Jyoti Shetty, Joel MalekSusan E. Van Aken, Steven Riedmuller, Herve Tettelin, Steven R. Gill, Owen White, Steven L. Salzberg, David L. Hoover, Luther E. Lindler, Shirley M. Halling, Stephen M. Boyle, Claire M. Fraser

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

413 Citations (Scopus)

Abstract

The 3.31-Mb genome sequence of the intracellular pathogen and potential bioterrorism agent, Brucella suis, was determined. Comparison of B. suis with Brucella melitensis has defined a finite set of differences that could be responsible for the differences in virulence and host preference between these organisms, and indicates that phage have played a significant role in their divergence. Analysis of the B. suis genome reveals transport and metabolic capabilities akin to soil/plant-associated bacteria. Extensive gene synteny between B. suis chromosome 1 and the genome of the plant symbiont Mesorhizobium loti emphasizes the similarity between this animal pathogen and plant pathogens and symbionts. A limited repertoire of genes homologous to known bacterial virulence factors were identified.

Original language	English
Pages (from-to)	13148-13153
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	99
Issue number	20
DOIs	https://doi.org/10.1073/pnas.192319099
Publication status	Published - 1 Oct 2002
Externally published	Yes

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Paulsen, I. T., Seshadri, R., Nelson, K. E., Eisen, J. A., Heidelberg, J. F., Read, T. D., Dodson, R. J., Umayam, L., Brinkac, L. M., Beanan, M. J., Daugherty, S. C., Deboy, R. T., Durkin, A. S., Kolonay, J. F., Madupu, R., Nelson, W. C., Ayodeji, B., Kraul, M., Shetty, J., ... Fraser, C. M. (2002). The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts. Proceedings of the National Academy of Sciences of the United States of America, 99(20), 13148-13153. https://doi.org/10.1073/pnas.192319099

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title = "The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts",

abstract = "The 3.31-Mb genome sequence of the intracellular pathogen and potential bioterrorism agent, Brucella suis, was determined. Comparison of B. suis with Brucella melitensis has defined a finite set of differences that could be responsible for the differences in virulence and host preference between these organisms, and indicates that phage have played a significant role in their divergence. Analysis of the B. suis genome reveals transport and metabolic capabilities akin to soil/plant-associated bacteria. Extensive gene synteny between B. suis chromosome 1 and the genome of the plant symbiont Mesorhizobium loti emphasizes the similarity between this animal pathogen and plant pathogens and symbionts. A limited repertoire of genes homologous to known bacterial virulence factors were identified.",

author = "Paulsen, {Ian T.} and Rekha Seshadri and Nelson, {Karen E.} and Eisen, {Jonathan A.} and Heidelberg, {John F.} and Read, {Timothy D.} and Dodson, {Robert J.} and Lowell Umayam and Brinkac, {Lauren M.} and Beanan, {Maureen J.} and Daugherty, {Sean C.} and Deboy, {Robert T.} and Durkin, {A. Scott} and Kolonay, {James F.} and Ramana Madupu and Nelson, {William C.} and Bola Ayodeji and Margaret Kraul and Jyoti Shetty and Joel Malek and {Van Aken}, {Susan E.} and Steven Riedmuller and Herve Tettelin and Gill, {Steven R.} and Owen White and Salzberg, {Steven L.} and Hoover, {David L.} and Lindler, {Luther E.} and Halling, {Shirley M.} and Boyle, {Stephen M.} and Fraser, {Claire M.}",

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doi = "10.1073/pnas.192319099",

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Paulsen, IT, Seshadri, R, Nelson, KE, Eisen, JA, Heidelberg, JF, Read, TD, Dodson, RJ, Umayam, L, Brinkac, LM, Beanan, MJ, Daugherty, SC, Deboy, RT, Durkin, AS, Kolonay, JF, Madupu, R, Nelson, WC, Ayodeji, B, Kraul, M, Shetty, J, Malek, J, Van Aken, SE, Riedmuller, S, Tettelin, H, Gill, SR, White, O, Salzberg, SL, Hoover, DL, Lindler, LE, Halling, SM, Boyle, SM & Fraser, CM 2002, 'The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts', Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 20, pp. 13148-13153. https://doi.org/10.1073/pnas.192319099

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T1 - The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts

AU - Paulsen, Ian T.

AU - Seshadri, Rekha

AU - Nelson, Karen E.

AU - Eisen, Jonathan A.

AU - Heidelberg, John F.

AU - Read, Timothy D.

AU - Dodson, Robert J.

AU - Umayam, Lowell

AU - Brinkac, Lauren M.

AU - Beanan, Maureen J.

AU - Daugherty, Sean C.

AU - Deboy, Robert T.

AU - Durkin, A. Scott

AU - Kolonay, James F.

AU - Madupu, Ramana

AU - Nelson, William C.

AU - Ayodeji, Bola

AU - Kraul, Margaret

AU - Shetty, Jyoti

AU - Malek, Joel

AU - Van Aken, Susan E.

AU - Riedmuller, Steven

AU - Tettelin, Herve

AU - Gill, Steven R.

AU - White, Owen

AU - Salzberg, Steven L.

AU - Hoover, David L.

AU - Lindler, Luther E.

AU - Halling, Shirley M.

AU - Boyle, Stephen M.

AU - Fraser, Claire M.

PY - 2002/10/1

Y1 - 2002/10/1

N2 - The 3.31-Mb genome sequence of the intracellular pathogen and potential bioterrorism agent, Brucella suis, was determined. Comparison of B. suis with Brucella melitensis has defined a finite set of differences that could be responsible for the differences in virulence and host preference between these organisms, and indicates that phage have played a significant role in their divergence. Analysis of the B. suis genome reveals transport and metabolic capabilities akin to soil/plant-associated bacteria. Extensive gene synteny between B. suis chromosome 1 and the genome of the plant symbiont Mesorhizobium loti emphasizes the similarity between this animal pathogen and plant pathogens and symbionts. A limited repertoire of genes homologous to known bacterial virulence factors were identified.

AB - The 3.31-Mb genome sequence of the intracellular pathogen and potential bioterrorism agent, Brucella suis, was determined. Comparison of B. suis with Brucella melitensis has defined a finite set of differences that could be responsible for the differences in virulence and host preference between these organisms, and indicates that phage have played a significant role in their divergence. Analysis of the B. suis genome reveals transport and metabolic capabilities akin to soil/plant-associated bacteria. Extensive gene synteny between B. suis chromosome 1 and the genome of the plant symbiont Mesorhizobium loti emphasizes the similarity between this animal pathogen and plant pathogens and symbionts. A limited repertoire of genes homologous to known bacterial virulence factors were identified.

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U2 - 10.1073/pnas.192319099

DO - 10.1073/pnas.192319099

M3 - Article

C2 - 12271122

AN - SCOPUS:0036791011

SN - 0027-8424

VL - 99

SP - 13148

EP - 13153

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 20

ER -

The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts

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