TY - JOUR
T1 - The burden of mild asthma
T2 - clinical burden and healthcare resource utilisation in the NOVELTY study
AU - Golam, Sarowar Muhammad
AU - Janson, Christer
AU - Beasley, Richard
AU - FitzGerald, J. Mark
AU - Harrison, Tim
AU - Chipps, Bradley
AU - Hughes, Rod
AU - Müllerová, Hana
AU - Olaguibel, José María
AU - Rapsomaniki, Eleni
AU - Reddel, Helen K.
AU - Sadatsafavi, Mohsen
AU - NOVELTY investigators
AU - Benhabib, Gabriel
AU - Mandhane, Piushkumar
AU - Bocca Ruiz, Xavier
AU - McIvor, Andrew
AU - del Olmo, Ricardo
AU - Pek, Bonavuth
AU - Lisanti, Raul Eduardo
AU - Petrella, Robert
AU - Marino, Gustavo
AU - Stollery, Daniel
AU - Mattarucco, Walter
AU - Chen, Meihua
AU - Nogueira, Juan
AU - Chen, Yan
AU - Parody, Maria
AU - Gu, Wei
AU - Pascale, Pablo
AU - Hui, Kim Ming Christopher
AU - Rodríguez, Pablo
AU - Li, Manxiang
AU - Silva, Damian
AU - Li, Shiyue
AU - Svetliza, Graciela
AU - Ma, Lijun
AU - Victorio, Carlos F.
AU - Qin, Guangyue
AU - Willigs Rolon, Roxana
AU - Song, Weidong
AU - Yañez, Anahí
AU - Tan, Wei
AU - Baines, Stuart
AU - Tang, Yijun
AU - Bowler, Simon
AU - Wang, Chen
AU - Bremner, Peter
AU - Wang, Tan
AU - Bull, Sheetal
AU - Wen, Fuqiang
AU - Carroll, Patrick
AU - Wu, Feng
AU - Challan, Mariam
AU - Xiang, PingChao
AU - Farah, Claude
AU - Xiao, Zuke
AU - Hammerschlag, Gary
AU - Xiong, Shengdao
AU - Hancock, Kerry
AU - Yang, Jinghua
AU - Harrington, Zinta
AU - Yang, Jingping
AU - Katsoulotos, Gregory
AU - Zhang, Caiqing
AU - Kim, Joshua
AU - Zhang, Min
AU - Langton, David
AU - Zhang, Ping
AU - Lee, Donald
AU - Zhang, Wei
AU - Peters, Matthew
N1 - Copyright the Author(s) 2022. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.
PY - 2022/8/12
Y1 - 2022/8/12
N2 - Background: Patients with mild asthma represent a substantial proportion of the population with asthma, yet there are limited data on their true burden of disease. We aimed to describe the clinical and healthcare resource utilisation (HCRU) burden of physician-assessed mild asthma.Methods: Patients with mild asthma were included from the NOVEL observational longiTudinal studY (NOVELTY; NCT02760329), a global, 3-year, real-world prospective study of patients with asthma and/or chronic obstructive pulmonary disease from community practice (specialised and primary care). Diagnosis and severity were based on physician discretion. Clinical burden included physician-reported exacerbations and patient-reported measures. HCRU included inpatient and outpatient visits.Results: Overall, 2004 patients with mild asthma were included; 22.8% experienced ≥1 exacerbation in the previous 12 months, of whom 72.3% experienced ≥1 severe exacerbation. Of 625 exacerbations reported, 48.0% lasted >1 week, 27.7% were preceded by symptomatic worsening lasting >3 days, and 50.1% required oral corticosteroid treatment. Health status was moderately impacted (St George's Respiratory Questionnaire score: 23.5 [standard deviation ± 17.9]). At baseline, 29.7% of patients had asthma symptoms that were not well controlled or very poorly controlled (Asthma Control Test score <20), increasing to 55.6% for those with ≥2 exacerbations in the previous year. In terms of HCRU, at least one unscheduled ambulatory visit for exacerbations was required by 9.5% of patients, including 9.2% requiring ≥1 emergency department visit and 1.1% requiring ≥1 hospital admission.Conclusions: In this global sample representing community practice, a significant proportion of patients with physician-assessed mild asthma had considerable clinical burden and HCRU.
AB - Background: Patients with mild asthma represent a substantial proportion of the population with asthma, yet there are limited data on their true burden of disease. We aimed to describe the clinical and healthcare resource utilisation (HCRU) burden of physician-assessed mild asthma.Methods: Patients with mild asthma were included from the NOVEL observational longiTudinal studY (NOVELTY; NCT02760329), a global, 3-year, real-world prospective study of patients with asthma and/or chronic obstructive pulmonary disease from community practice (specialised and primary care). Diagnosis and severity were based on physician discretion. Clinical burden included physician-reported exacerbations and patient-reported measures. HCRU included inpatient and outpatient visits.Results: Overall, 2004 patients with mild asthma were included; 22.8% experienced ≥1 exacerbation in the previous 12 months, of whom 72.3% experienced ≥1 severe exacerbation. Of 625 exacerbations reported, 48.0% lasted >1 week, 27.7% were preceded by symptomatic worsening lasting >3 days, and 50.1% required oral corticosteroid treatment. Health status was moderately impacted (St George's Respiratory Questionnaire score: 23.5 [standard deviation ± 17.9]). At baseline, 29.7% of patients had asthma symptoms that were not well controlled or very poorly controlled (Asthma Control Test score <20), increasing to 55.6% for those with ≥2 exacerbations in the previous year. In terms of HCRU, at least one unscheduled ambulatory visit for exacerbations was required by 9.5% of patients, including 9.2% requiring ≥1 emergency department visit and 1.1% requiring ≥1 hospital admission.Conclusions: In this global sample representing community practice, a significant proportion of patients with physician-assessed mild asthma had considerable clinical burden and HCRU.
KW - Disease burden
KW - Healthcare resource utilisation
KW - Longitudinal studies
KW - Mild asthma
KW - Patient-reported measures
UR - http://www.scopus.com/inward/record.url?scp=85135716693&partnerID=8YFLogxK
U2 - 10.1016/j.rmed.2022.106863
DO - 10.1016/j.rmed.2022.106863
M3 - Article
C2 - 35952579
SN - 0954-6111
VL - 200
SP - 1
EP - 9
JO - Respiratory Medicine
JF - Respiratory Medicine
M1 - 106863
ER -