The clinical features, management and outcomes of lymphoma in pregnancy: a multicentre study by the Australasian Lymphoma Alliance

Pietro R. Di Ciaccio, Georgia Mills, Michael J. Shipton, Belinda Campbell, Gareth Gregory, Jenna Langfield, Matthew Greenwood, Sean McKeague, Mohammad Shanavas, Renee Eslick, Giselle Kidson-Gerber, Portia Smallbone, Catherine Tang, Kirk Morris, Ian Bilmon, Costas K. Yannakou, Xavier Badoux, Leanne Berkahn, Sergio Farina, Kylie D. MasonPenelope Motum, Kathryn Goss, Nada Hamad*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)
45 Downloads (Pure)

Abstract

Lymphoma in pregnancy (LIP) presents unique clinical, social and ethical challenges; however, the evidence regarding this clinical scenario is limited. We conducted a multicentre retrospective observational study reporting on the features, management, and outcomes of LIP in patients diagnosed between January 2009 and December 2020 at 16 sites in Australia and New Zealand for the first time. We included diagnoses occurring either during pregnancy or within the first 12 months following delivery. A total of 73 patients were included, 41 diagnosed antenatally (AN cohort) and 32 postnatally (PN cohort). The most common diagnoses were Hodgkin lymphoma (HL; 40 patients), diffuse large B-cell lymphoma (DLBCL; 11) and primary mediastinal B-cell lymphoma (PMBCL; six). At a median follow up of 2.37 years, the 2- and 5-year overall survival (OS) for patients with HL were 91% and 82%. For the combined DLBCL and PMBCL group, the 2-year OS was 92%. Standard curative chemotherapy regimens were successfully delivered to 64% of women in the AN cohort; however, counselling regarding future fertility and termination of pregnancy were suboptimal, and a standardised approach to staging lacking. Neonatal outcomes were generally favourable. We present a large multicentre cohort of LIP reflecting contemporary practice and identify areas in need of ongoing research.

Original languageEnglish
Pages (from-to)887-896
Number of pages10
JournalBritish Journal of Haematology
Volume201
Issue number5
DOIs
Publication statusPublished - Jun 2023

Bibliographical note

Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • counselling
  • lymphoma
  • neonatology
  • outcomes research
  • pregnancy

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