The clinical significance of CD4 counts in Asian and Caucasian HIV-infected populations

results from TAHOD and AHOD

Amit C. Achhra, Jialun Zhou, Jun Yong Choi, Jennifer Hoy, Fujie Zhang, David J. Templeton, Tuti Merati, Ian Woolley, Kathy Petoumenos, Janaki Amin

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The significance of interethnic variation in CD4 counts between Asian and Caucasian populations is not known. Patients on combination antiretroviral therapy from Treat Asia and Australian HIV Observational Databases (TAHOD, predominantly Asian, n = 3356; and AHOD, predominantly Caucasian, n = 2312, respectively) were followed for 23 144 person-years for AIDS/death and all-cause mortality endpoints. We calculated incidence-rates and used adjusted Cox regression to test for the interaction between cohort (TAHOD/AHOD) and time-updated CD4 count category (lagged by 3 months) for each of the endpoints. There were 382 AIDS/death events in TAHOD (rate: 4.06, 95%CI: 3.68-4.50) and 305 in AHOD (rate: 2.39, 95%CI: 2.13-2.67), per 100 person-years. At any given CD4 count category, the incidence-rates of endpoints were found to be similar between TAHOD and AHOD (in the adjusted models, P >.05 for the interaction term between cohort type and latest CD4 counts). At any given CD4 count, risk of AIDS or death was not found to vary by ethnicity, suggesting that the CD4 count thresholds for predicting outcomes defined in Caucasian populations may be equally valid in Asian populations.

Original languageEnglish
Pages (from-to)160-170
Number of pages11
JournalJournal of the International Association of Physicians in AIDS Care
Volume10
Issue number3
DOIs
Publication statusPublished - May 2011
Externally publishedYes

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Keywords

  • Asians
  • Caucasian race
  • CD4 counts
  • cohort analysis
  • ethnicity

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