TY - JOUR
T1 - The clock drawing test as a screening tool in mild cognitive impairment and very mild dementia
T2 - a new brief method of scoring and normative data in the elderly
AU - Ricci, Monica
AU - Pigliautile, Martina
AU - D’Ambrosio, Valeria
AU - Ercolani, Sara
AU - Bianchini, Cinzia
AU - Ruggiero, Carmelinda
AU - Vanacore, Nicola
AU - Mecocci, Patrizia
PY - 2016/6/1
Y1 - 2016/6/1
N2 - many studies sustained that the clock drawing test (CDT) was not able to accurately detect people with CDR = 0.5. Other researchers have promoted the use of scoring approaches with multiple scales that rate quantitative and qualitative features of the production. Nevertheless, these scoring systems are complex and time-consuming. We propose a new brief CDT’ scoring system in order to find a good measure for mild cognitive decline which is at the same time easy to administer. we enrolled 719 subjects: n. 181 with mild Alzheimer’s disease (AD); n. 200 with amnesic mild cognitive impairment (MCI) and n. 338 healthy elderly subjects (C). our CDT-three-cluster scoring system demonstrated a good sensitivity and an excellent specificity to discriminate MCI subjects from normal elderly (76 and 84 %, respectively) and an excellent sensitivity and specificity to discriminate patients affected by mild Alzheimer disease (CDR: 1) from normal elderly (91 and 90 %, respectively). We found that CDT’ score = 1.30 discriminate people with MCI, whereas a score = 4.38 discriminate AD patients. The three-cluster-scoring-system demonstrated a good diagnostic accuracy, taking into account those error-items more predictive of cognitive decline: omission of numbers or hands, writing numbers or hands in a wrong position and writing numbers or hands in a different code. Our CDT’ scoring system is very short and easy method which can be used also by non-specialist.
AB - many studies sustained that the clock drawing test (CDT) was not able to accurately detect people with CDR = 0.5. Other researchers have promoted the use of scoring approaches with multiple scales that rate quantitative and qualitative features of the production. Nevertheless, these scoring systems are complex and time-consuming. We propose a new brief CDT’ scoring system in order to find a good measure for mild cognitive decline which is at the same time easy to administer. we enrolled 719 subjects: n. 181 with mild Alzheimer’s disease (AD); n. 200 with amnesic mild cognitive impairment (MCI) and n. 338 healthy elderly subjects (C). our CDT-three-cluster scoring system demonstrated a good sensitivity and an excellent specificity to discriminate MCI subjects from normal elderly (76 and 84 %, respectively) and an excellent sensitivity and specificity to discriminate patients affected by mild Alzheimer disease (CDR: 1) from normal elderly (91 and 90 %, respectively). We found that CDT’ score = 1.30 discriminate people with MCI, whereas a score = 4.38 discriminate AD patients. The three-cluster-scoring-system demonstrated a good diagnostic accuracy, taking into account those error-items more predictive of cognitive decline: omission of numbers or hands, writing numbers or hands in a wrong position and writing numbers or hands in a different code. Our CDT’ scoring system is very short and easy method which can be used also by non-specialist.
KW - mild Alzheimer’s disease
KW - mild cognitive impairment
KW - clock drawing test
KW - scoring system
UR - http://www.scopus.com/inward/record.url?scp=84957668477&partnerID=8YFLogxK
U2 - 10.1007/s10072-016-2480-6
DO - 10.1007/s10072-016-2480-6
M3 - Article
C2 - 26863871
AN - SCOPUS:84957668477
SN - 1590-1874
VL - 37
SP - 867
EP - 873
JO - Neurological Sciences
JF - Neurological Sciences
IS - 6
ER -