The contractile lability of smooth muscle in asthmatic airway hyperresponsiveness

Laurence Auger; Samuel Mailhot-Larouche; Francis Tremblay; Mathilde Poirier; Claude Farah; Ynuk Bossé

doi:10.1586/17476348.2016.1111764

The contractile lability of smooth muscle in asthmatic airway hyperresponsiveness

Laurence Auger, Samuel Mailhot-Larouche, Francis Tremblay, Mathilde Poirier, Claude Farah, Ynuk Bossé^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

16 Citations (Scopus)

Abstract

The contractile capacity of airway smooth muscle is not fixed but modulated by an impressive number of extracellular inflammatory mediators. Targeting the transient component of airway hyperresponsiveness ascribed to this contractile lability of ASM is a quest of great promises in order to alleviate asthma symptoms during inflammatory flares. However, owing to the plethora of mediators putatively involved and the molecular heterogeneity of asthma, it is more likely that many mediators conspire to increase the contractile capacity of ASM, each of which contributing to a various extent and in a time-varying fashion in individuals suffering from asthma. The task of identifying a common mend for a tissue rendered hypercontractile by imponderable assortments of inflammatory mediators is puzzling.

Original language	English
Pages (from-to)	19-27
Number of pages	9
Journal	Expert Review of Respiratory Medicine
Volume	10
Issue number	1
DOIs	https://doi.org/10.1586/17476348.2016.1111764
Publication status	Published - 1 Jan 2016
Externally published	Yes

Keywords

Airway hyperresponsiveness
Airway smooth muscle
Asthma
Contractile lability
Inflammation

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10.1586/17476348.2016.1111764

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abstract = "The contractile capacity of airway smooth muscle is not fixed but modulated by an impressive number of extracellular inflammatory mediators. Targeting the transient component of airway hyperresponsiveness ascribed to this contractile lability of ASM is a quest of great promises in order to alleviate asthma symptoms during inflammatory flares. However, owing to the plethora of mediators putatively involved and the molecular heterogeneity of asthma, it is more likely that many mediators conspire to increase the contractile capacity of ASM, each of which contributing to a various extent and in a time-varying fashion in individuals suffering from asthma. The task of identifying a common mend for a tissue rendered hypercontractile by imponderable assortments of inflammatory mediators is puzzling.",

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AU - Farah, Claude

AU - Bossé, Ynuk

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AB - The contractile capacity of airway smooth muscle is not fixed but modulated by an impressive number of extracellular inflammatory mediators. Targeting the transient component of airway hyperresponsiveness ascribed to this contractile lability of ASM is a quest of great promises in order to alleviate asthma symptoms during inflammatory flares. However, owing to the plethora of mediators putatively involved and the molecular heterogeneity of asthma, it is more likely that many mediators conspire to increase the contractile capacity of ASM, each of which contributing to a various extent and in a time-varying fashion in individuals suffering from asthma. The task of identifying a common mend for a tissue rendered hypercontractile by imponderable assortments of inflammatory mediators is puzzling.

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The contractile lability of smooth muscle in asthmatic airway hyperresponsiveness

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