The cost-effectiveness of outpatient (at home) cervical ripening with isosorbide mononitrate prior to induction of labour

O. Eddama*, S. Petrou, L. Schroeder, S. S. Bollapragada, F. Mackenzie, J. Norrie, M. Reid, J. E. Norman

*Corresponding author for this work

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Objectives

To assess the cost-effectiveness of outpatient (at home) cervical ripening with isosorbide mononitrate (IMN) prior to induction of labour.

Design

Economic evaluation was conducted alongside a randomised placebo controlled trial (the IMOP trial).

Setting

Large UK maternity hospital.

Population

A total of 350 nulliparous women with a singleton pregnancy, cephalic presentation >= 37 weeks gestation, requiring cervical ripening prior to induction of labour.

Interventions

Isosorbide mononitrate (n = 177) or placebo (n = 173) self-administered vaginally at home at 48, 32 and 16 hours prior to the scheduled time of admission for induction.

Results

Mean health service costs between the period of randomisation and discharge for mother and infant were 1254.86 pound in the IMN group and 1242.88 pound in the placebo group, generating a mean cost difference of 11.98 pound (bootstrap mean cost difference 12.86; pound 95%CI: -106.79 pound, 129.39) pound that was not statistically significant (P = 0.842). The incremental cost per hour prevented from hospital admission to delivery was 7.53 pound. At the notional willingness to pay threshold of 100 pound per hour prevented from hospital admission to delivery, the probability that IMN is cost-effective was estimated at 0.67. This translated into a mean net monetary benefit of 98.13 pound for each woman given IMN.

Conclusions

Although the probability that IMN is cost-effective approaches 0.7 at seemingly low willingness to pay thresholds for an hour prevented from hospital admission to delivery, our results should be viewed in the light of the clinical findings from the IMOP trial.

Original languageEnglish
Pages (from-to)1196-1203
Number of pages8
JournalBJOG: An International Journal of Obstetrics & Gynaecology
Volume116
Issue number9
DOIs
Publication statusPublished - Aug 2009
Externally publishedYes

Keywords

  • Economic evaluation
  • induction of labour
  • isosorbide mononitrate
  • obstetrics
  • NITRIC-OXIDE
  • WOMENS PREFERENCES
  • INTRAPARTUM CARE
  • INFORMATION
  • TRIAL

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