The cycling of combination antirheumatic drug therapy in rheumatoid arthritis

A C Schwarzer; M H Arnold; D Kelly; Mike Jones; E. Beller; P J McNaught; Leslie Schrieber; P M Brooks

The cycling of combination antirheumatic drug therapy in rheumatoid arthritis

A C Schwarzer, M H Arnold, D Kelly, Mike Jones, E. Beller, P J McNaught, Leslie Schrieber, P M Brooks

Research output: Contribution to journal › Article › peer-review

Abstract

In this open pilot study a combination of hydroxychloroquine, prednisolone and alternating months of treatment with sulphasalazine or oral weekly pulse methotrexate has been investigated in 16 patients with rheumatoid arthritis (RA) refractory to a total of 67 disease suppressive medications. Results at 3 months indicated significant improvements in visual analogue score for pain, joint count, Ritchie index, scale of disability related to activities of daily living, ESR, rheumatoid factor and C-reactive protein. This degree of improvement, however, was not maintained 6 and 12 months after commencement of treatment. Pain score, Ritchie index and ESR were the only parameters demonstrating significant improvement at 12 months. Therapy was terminated in eight patients, half due to lack of efficacy and half because of side effects.

Original language	English
Pages (from-to)	445-50
Number of pages	6
Journal	British journal of rheumatology
Volume	29
Issue number	6
Publication status	Published - Dec 1990
Externally published	Yes

Keywords

Activities of Daily Living
Anti-Inflammatory Agents
Arthritis, Rheumatoid
C-Reactive Protein
Drug Therapy, Combination
Female
Humans
Male
Middle Aged
Pain Measurement
Pilot Projects
Rheumatoid Factor
Severity of Illness Index
Time Factors
Journal Article
Research Support, Non-U.S. Gov't

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https://www.ncbi.nlm.nih.gov/pubmed/2257452

Cite this

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title = "The cycling of combination antirheumatic drug therapy in rheumatoid arthritis",

abstract = "In this open pilot study a combination of hydroxychloroquine, prednisolone and alternating months of treatment with sulphasalazine or oral weekly pulse methotrexate has been investigated in 16 patients with rheumatoid arthritis (RA) refractory to a total of 67 disease suppressive medications. Results at 3 months indicated significant improvements in visual analogue score for pain, joint count, Ritchie index, scale of disability related to activities of daily living, ESR, rheumatoid factor and C-reactive protein. This degree of improvement, however, was not maintained 6 and 12 months after commencement of treatment. Pain score, Ritchie index and ESR were the only parameters demonstrating significant improvement at 12 months. Therapy was terminated in eight patients, half due to lack of efficacy and half because of side effects.",

keywords = "Activities of Daily Living, Anti-Inflammatory Agents, Arthritis, Rheumatoid, C-Reactive Protein, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Pain Measurement, Pilot Projects, Rheumatoid Factor, Severity of Illness Index, Time Factors, Journal Article, Research Support, Non-U.S. Gov't",

author = "Schwarzer, {A C} and Arnold, {M H} and D Kelly and Mike Jones and E. Beller and McNaught, {P J} and Leslie Schrieber and Brooks, {P M}",

year = "1990",

month = dec,

language = "English",

volume = "29",

pages = "445--50",

journal = "British journal of rheumatology",

issn = "0263-7103",

publisher = "Oxford University Press",

number = "6",

}

TY - JOUR

T1 - The cycling of combination antirheumatic drug therapy in rheumatoid arthritis

AU - Schwarzer, A C

AU - Arnold, M H

AU - Kelly, D

AU - Jones, Mike

AU - Beller, E.

AU - McNaught, P J

AU - Schrieber, Leslie

AU - Brooks, P M

PY - 1990/12

Y1 - 1990/12

N2 - In this open pilot study a combination of hydroxychloroquine, prednisolone and alternating months of treatment with sulphasalazine or oral weekly pulse methotrexate has been investigated in 16 patients with rheumatoid arthritis (RA) refractory to a total of 67 disease suppressive medications. Results at 3 months indicated significant improvements in visual analogue score for pain, joint count, Ritchie index, scale of disability related to activities of daily living, ESR, rheumatoid factor and C-reactive protein. This degree of improvement, however, was not maintained 6 and 12 months after commencement of treatment. Pain score, Ritchie index and ESR were the only parameters demonstrating significant improvement at 12 months. Therapy was terminated in eight patients, half due to lack of efficacy and half because of side effects.

AB - In this open pilot study a combination of hydroxychloroquine, prednisolone and alternating months of treatment with sulphasalazine or oral weekly pulse methotrexate has been investigated in 16 patients with rheumatoid arthritis (RA) refractory to a total of 67 disease suppressive medications. Results at 3 months indicated significant improvements in visual analogue score for pain, joint count, Ritchie index, scale of disability related to activities of daily living, ESR, rheumatoid factor and C-reactive protein. This degree of improvement, however, was not maintained 6 and 12 months after commencement of treatment. Pain score, Ritchie index and ESR were the only parameters demonstrating significant improvement at 12 months. Therapy was terminated in eight patients, half due to lack of efficacy and half because of side effects.

KW - Activities of Daily Living

KW - Anti-Inflammatory Agents

KW - Arthritis, Rheumatoid

KW - C-Reactive Protein

KW - Drug Therapy, Combination

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Pain Measurement

KW - Pilot Projects

KW - Rheumatoid Factor

KW - Severity of Illness Index

KW - Time Factors

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - Article

C2 - 2257452

SN - 0263-7103

VL - 29

SP - 445

EP - 450

JO - British journal of rheumatology

JF - British journal of rheumatology

IS - 6

ER -

The cycling of combination antirheumatic drug therapy in rheumatoid arthritis

Abstract

Keywords

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