TY - JOUR
T1 - The development of a novel high-dose pressurized aerosol dry-powder device (PADD) for the delivery of pumactant for inhalation therapy
AU - Young, Paul M.
AU - Thompson, Jim
AU - Woodcock, Derek
AU - Aydin, Mo
AU - Price, Robert
PY - 2004/6
Y1 - 2004/6
N2 - The performance of a novel dry powder inhaler designed to deliver exceptionally high doses was investigated using pumactant as a model powder. Pumactant (a synthetic lung surfactant consisting of a phospholipid mixture), with a 90th percentile particle size of 2.92 μm is highly cohesive, has a high moisture affinity (6.2% w/w at 45% RH), and is predominately amorphous. The device (pressurized aerosol dry-powder delivery [PADD]) utilizes pressurized gas to aerosolize a powder bed from a reservoir and delivers it through a conventional mouthpiece. The influence of loaded dose on dry powder delivery and can pressure on aerosolization efficiency was investigated. Analysis of the delivered dose studies suggested a linear relationship between loaded dose and delivered dose (R2 = 0.96, for loaded doses of 0–250 mg), with a delivery efficiency of 70%. Analysis of the aerosolization efficiency using a Marple Miller type impactor suggested fine particle fractions (particles with an aerodynamic diameter of <5 μm) of approximately 30% using canister pressures of 8–14 bars. These results indicate that the PADD device may be a useful tool in delivering high-dose medicaments, as a carrier-free formulation, to the deep lung.
AB - The performance of a novel dry powder inhaler designed to deliver exceptionally high doses was investigated using pumactant as a model powder. Pumactant (a synthetic lung surfactant consisting of a phospholipid mixture), with a 90th percentile particle size of 2.92 μm is highly cohesive, has a high moisture affinity (6.2% w/w at 45% RH), and is predominately amorphous. The device (pressurized aerosol dry-powder delivery [PADD]) utilizes pressurized gas to aerosolize a powder bed from a reservoir and delivers it through a conventional mouthpiece. The influence of loaded dose on dry powder delivery and can pressure on aerosolization efficiency was investigated. Analysis of the delivered dose studies suggested a linear relationship between loaded dose and delivered dose (R2 = 0.96, for loaded doses of 0–250 mg), with a delivery efficiency of 70%. Analysis of the aerosolization efficiency using a Marple Miller type impactor suggested fine particle fractions (particles with an aerodynamic diameter of <5 μm) of approximately 30% using canister pressures of 8–14 bars. These results indicate that the PADD device may be a useful tool in delivering high-dose medicaments, as a carrier-free formulation, to the deep lung.
KW - device technology
KW - high-dose formulations
KW - dry powder
KW - inhalation pumactant
KW - surfactant
UR - http://www.scopus.com/inward/record.url?scp=3242685863&partnerID=8YFLogxK
U2 - 10.1089/0894268041457219
DO - 10.1089/0894268041457219
M3 - Article
C2 - 15294062
VL - 17
SP - 123
EP - 128
JO - Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung
JF - Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung
IS - 2
ER -