TY - JOUR
T1 - The dynamics of CD147 in Alzheimer's disease development and pathology
AU - Kanyenda, Limbikani J.
AU - Verdile, Giuseppe
AU - Boulos, Sherif
AU - Krishnaswamy, Sudarsan
AU - Taddei, Kevin
AU - Meloni, Bruno P.
AU - Mastaglia, Frank L.
AU - Martins, Ralph N.
PY - 2011
Y1 - 2011
N2 - CD147, also known as basigin, EMMPRIN, neurothelin, TCSF, M6, HT7, OX47, or gp42, is a transmembrane glycoprotein of the immunoglobulin super-family. It is expressed in many neuronal and non-neuronal tissues including the hippocampus, pre-frontal cortex thyroid, heart, early erythroid, amygdala, and placenta. This protein is involved in various cellular and biological functions, such as lymphocyte migration and maturation, tissue repair cancer progression, T and B lymphocyte activation, and induction of extracellular matrix metalloproteinase. The CD147 protein interacts with other proteins such as cyclophilin A (CyPA), Cyclophilin B (CyPB), sterol carrier protein (SCP), caveolin-1 and integrins, and can influence amyloid-β (Aβ) peptide levels, a protein that is central to Alzheimer's disease (AD) pathogenesis. Mechanisms by which CD147 regulate Aβ levels remain unclear, thus in this review we discuss its involvement in Aβ production and clearance and potential mechanisms by which controlling CD147 levels could impact on Aβ accumulation and AD pathogenesis.
AB - CD147, also known as basigin, EMMPRIN, neurothelin, TCSF, M6, HT7, OX47, or gp42, is a transmembrane glycoprotein of the immunoglobulin super-family. It is expressed in many neuronal and non-neuronal tissues including the hippocampus, pre-frontal cortex thyroid, heart, early erythroid, amygdala, and placenta. This protein is involved in various cellular and biological functions, such as lymphocyte migration and maturation, tissue repair cancer progression, T and B lymphocyte activation, and induction of extracellular matrix metalloproteinase. The CD147 protein interacts with other proteins such as cyclophilin A (CyPA), Cyclophilin B (CyPB), sterol carrier protein (SCP), caveolin-1 and integrins, and can influence amyloid-β (Aβ) peptide levels, a protein that is central to Alzheimer's disease (AD) pathogenesis. Mechanisms by which CD147 regulate Aβ levels remain unclear, thus in this review we discuss its involvement in Aβ production and clearance and potential mechanisms by which controlling CD147 levels could impact on Aβ accumulation and AD pathogenesis.
KW - γ-secretase
KW - Alzheimer's disease
KW - amyloid-β
KW - amyloid-β protein precursor
KW - CD147
KW - cholesterol
KW - EMMPRIN
KW - immunoglobulin superfamily
KW - sterol carrier protein-2
UR - http://www.scopus.com/inward/record.url?scp=80055035017&partnerID=8YFLogxK
U2 - 10.3233/JAD-2011-110584
DO - 10.3233/JAD-2011-110584
M3 - Review article
C2 - 21694447
AN - SCOPUS:80055035017
SN - 1387-2877
VL - 26
SP - 593
EP - 605
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 4
ER -