The dynamics of CD147 in Alzheimer's disease development and pathology

Limbikani J. Kanyenda, Giuseppe Verdile, Sherif Boulos, Sudarsan Krishnaswamy, Kevin Taddei, Bruno P. Meloni, Frank L. Mastaglia, Ralph N. Martins*

*Corresponding author for this work

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

CD147, also known as basigin, EMMPRIN, neurothelin, TCSF, M6, HT7, OX47, or gp42, is a transmembrane glycoprotein of the immunoglobulin super-family. It is expressed in many neuronal and non-neuronal tissues including the hippocampus, pre-frontal cortex thyroid, heart, early erythroid, amygdala, and placenta. This protein is involved in various cellular and biological functions, such as lymphocyte migration and maturation, tissue repair cancer progression, T and B lymphocyte activation, and induction of extracellular matrix metalloproteinase. The CD147 protein interacts with other proteins such as cyclophilin A (CyPA), Cyclophilin B (CyPB), sterol carrier protein (SCP), caveolin-1 and integrins, and can influence amyloid-β (Aβ) peptide levels, a protein that is central to Alzheimer's disease (AD) pathogenesis. Mechanisms by which CD147 regulate Aβ levels remain unclear, thus in this review we discuss its involvement in Aβ production and clearance and potential mechanisms by which controlling CD147 levels could impact on Aβ accumulation and AD pathogenesis.

Original languageEnglish
Pages (from-to)593-605
Number of pages13
JournalJournal of Alzheimer's Disease
Volume26
Issue number4
DOIs
Publication statusPublished - 2011
Externally publishedYes

Keywords

  • γ-secretase
  • Alzheimer's disease
  • amyloid-β
  • amyloid-β protein precursor
  • CD147
  • cholesterol
  • EMMPRIN
  • immunoglobulin superfamily
  • sterol carrier protein-2

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  • Cite this

    Kanyenda, L. J., Verdile, G., Boulos, S., Krishnaswamy, S., Taddei, K., Meloni, B. P., ... Martins, R. N. (2011). The dynamics of CD147 in Alzheimer's disease development and pathology. Journal of Alzheimer's Disease, 26(4), 593-605. https://doi.org/10.3233/JAD-2011-110584