The effect of a peripheral vasconstrictor drug on the systemic arterial oxygen saturation in eisenmenger's syndrome

Sean Blake*, Sally F. Bonar, Peter Blake, John Garrett

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Eisenmenger's syndrome is associated with a high mortality rate. Pregnancy is particularly hazardous, carrying a death rate of at least 30%. Death is usually attributed to anoxaemia due either to a fall in the systemic vascular resistance or a rise in the pulmonary resistance. On this basis a peripheral vasoconstrictor drug has frequently been recommended as an appropriate form of treatment. To assess this recommendation a patient with Eisenmenger's syndrome was administered the vasoconstrictor drug phenylephrine during diagnostic cardiac catheterisation. This resulted in. a fall rather than a rise in the systemic arterial oxygen saturation. The result provides a caution about the advisability of administering a vasoconstrictor drug to an Eisenmenger patient.

Original languageEnglish
Pages (from-to)319-320
Number of pages2
JournalIrish Journal of Medical Science
Volume153
Issue number9
DOIs
Publication statusPublished - Sep 1984
Externally publishedYes

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