The effect of disease risk probability and disease type on interest in clinic-based versus direct-to-consumer genetic testing services

Kerry Sherman*, Laura Kate Shaw, Katrina Champion, Fernanda Caldeira, Margaret McCaskill

*Corresponding author for this work

Research output: Contribution to journalArticle

4 Citations (Scopus)


The effect of disease-specific cognitions on interest in clinic-based and direct-to-consumer (DTC) genetic testing was assessed. Participants (N = 309) responded to an online hypothetical scenario and received genetic testing-related messages that varied by risk probability (25, 50, 75 %) and disease type (Alzheimer’s disease vs. Type 2 Diabetes). Post-manipulation interest increased for both testing types, but was greater for clinic-based testing. Interest was greater for Type 2 Diabetes than for Alzheimer’s disease, the latter perceived as more severe and likely, and less treatable and preventable. For DTC testing only, participants allocated to the high risk condition (75 %) had greater testing interest than those in the low (25 %) category. DTC testing is perceived as a viable, but less preferred, option compared with clinic-based testing. Particularly when considering DTC genetic testing, there is a need to emphasize subjective disease-related perceptions, including risk probability.

Original languageEnglish
Pages (from-to)706-714
Number of pages9
JournalJournal of Behavioral Medicine
Issue number5
Publication statusPublished - 21 Oct 2015


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