The effect of exercise on large artery haemodynamics in cystic fibrosis

James H. Hull*, Les Ansley, Charlotte E. Bolton, James E. Sharman, Ronald K. Knight, John R. Cockcroft, Dennis J. Shale, Rachel Garrod

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    17 Citations (Scopus)

    Abstract

    Background: Adult patients with cystic fibrosis (CF) have resting abnormal large artery haemodynamics. Here, we obtain further insight in patients with CF by evaluating haemodynamic response to physiological stress. Methods: Thirty-six stable CF patients mean (SD) age 28.9 (9.0)years and 25 controls matched for age, gender and body mass index were studied. Central haemodynamic parameters; including augmentation index (AIx) and wasted left ventricular pressure energy (EW) were determined pre, during and post light intensity cycle ergometry. Results: During exercise, despite a similar heart rate and blood pressure, patients had comparatively greater EW (P=0.03) and trend towards greater AIx (P=0.07) than controls. Exercise EW was greatest in patients with CF related diabetes (n=11). In all subjects, exercise EW was related to age (r=0.54, P<0.001) and FEV1% predicted (r=-0.32, P=0.01). Conclusions: Adults with CF have an abnormal haemodynamic response to exercise. This finding has deleterious implications for myocardial performance.

    Original languageEnglish
    Pages (from-to)121-127
    Number of pages7
    JournalJournal of Cystic Fibrosis
    Volume10
    Issue number2
    DOIs
    Publication statusPublished - Mar 2011

    Keywords

    • Arterial stiffness
    • Cardiovascular
    • Diabetes mellitus
    • Exercise
    • Inflammation

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