The effect of exercise on large artery haemodynamics in cystic fibrosis

James H. Hull; Les Ansley; Charlotte E. Bolton; James E. Sharman; Ronald K. Knight; John R. Cockcroft; Dennis J. Shale; Rachel Garrod

doi:10.1016/j.jcf.2010.12.001

The effect of exercise on large artery haemodynamics in cystic fibrosis

James H. Hull^*, Les Ansley, Charlotte E. Bolton, James E. Sharman, Ronald K. Knight, John R. Cockcroft, Dennis J. Shale, Rachel Garrod

^*Corresponding author for this work

Research output: Contribution to journal › Article

16 Citations (Scopus)

Abstract

Background: Adult patients with cystic fibrosis (CF) have resting abnormal large artery haemodynamics. Here, we obtain further insight in patients with CF by evaluating haemodynamic response to physiological stress. Methods: Thirty-six stable CF patients mean (SD) age 28.9 (9.0)years and 25 controls matched for age, gender and body mass index were studied. Central haemodynamic parameters; including augmentation index (AIx) and wasted left ventricular pressure energy (E_W) were determined pre, during and post light intensity cycle ergometry. Results: During exercise, despite a similar heart rate and blood pressure, patients had comparatively greater E_W (P=0.03) and trend towards greater AIx (P=0.07) than controls. Exercise E_W was greatest in patients with CF related diabetes (n=11). In all subjects, exercise E_W was related to age (r=0.54, P<0.001) and FEV₁% predicted (r=-0.32, P=0.01). Conclusions: Adults with CF have an abnormal haemodynamic response to exercise. This finding has deleterious implications for myocardial performance.

Original language	English
Pages (from-to)	121-127
Number of pages	7
Journal	Journal of Cystic Fibrosis
Volume	10
Issue number	2
DOIs	https://doi.org/10.1016/j.jcf.2010.12.001
Publication status	Published - Mar 2011

Keywords

Arterial stiffness
Cardiovascular
Diabetes mellitus
Exercise
Inflammation

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Hull, J. H., Ansley, L., Bolton, C. E., Sharman, J. E., Knight, R. K., Cockcroft, J. R., ... Garrod, R. (2011). The effect of exercise on large artery haemodynamics in cystic fibrosis. Journal of Cystic Fibrosis, 10(2), 121-127. https://doi.org/10.1016/j.jcf.2010.12.001

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abstract = "Background: Adult patients with cystic fibrosis (CF) have resting abnormal large artery haemodynamics. Here, we obtain further insight in patients with CF by evaluating haemodynamic response to physiological stress. Methods: Thirty-six stable CF patients mean (SD) age 28.9 (9.0)years and 25 controls matched for age, gender and body mass index were studied. Central haemodynamic parameters; including augmentation index (AIx) and wasted left ventricular pressure energy (EW) were determined pre, during and post light intensity cycle ergometry. Results: During exercise, despite a similar heart rate and blood pressure, patients had comparatively greater EW (P=0.03) and trend towards greater AIx (P=0.07) than controls. Exercise EW was greatest in patients with CF related diabetes (n=11). In all subjects, exercise EW was related to age (r=0.54, P<0.001) and FEV1{\%} predicted (r=-0.32, P=0.01). Conclusions: Adults with CF have an abnormal haemodynamic response to exercise. This finding has deleterious implications for myocardial performance.",

keywords = "Arterial stiffness, Cardiovascular, Diabetes mellitus, Exercise, Inflammation",

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AU - Ansley, Les

AU - Bolton, Charlotte E.

AU - Sharman, James E.

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AU - Cockcroft, John R.

AU - Shale, Dennis J.

AU - Garrod, Rachel

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N2 - Background: Adult patients with cystic fibrosis (CF) have resting abnormal large artery haemodynamics. Here, we obtain further insight in patients with CF by evaluating haemodynamic response to physiological stress. Methods: Thirty-six stable CF patients mean (SD) age 28.9 (9.0)years and 25 controls matched for age, gender and body mass index were studied. Central haemodynamic parameters; including augmentation index (AIx) and wasted left ventricular pressure energy (EW) were determined pre, during and post light intensity cycle ergometry. Results: During exercise, despite a similar heart rate and blood pressure, patients had comparatively greater EW (P=0.03) and trend towards greater AIx (P=0.07) than controls. Exercise EW was greatest in patients with CF related diabetes (n=11). In all subjects, exercise EW was related to age (r=0.54, P<0.001) and FEV1% predicted (r=-0.32, P=0.01). Conclusions: Adults with CF have an abnormal haemodynamic response to exercise. This finding has deleterious implications for myocardial performance.

AB - Background: Adult patients with cystic fibrosis (CF) have resting abnormal large artery haemodynamics. Here, we obtain further insight in patients with CF by evaluating haemodynamic response to physiological stress. Methods: Thirty-six stable CF patients mean (SD) age 28.9 (9.0)years and 25 controls matched for age, gender and body mass index were studied. Central haemodynamic parameters; including augmentation index (AIx) and wasted left ventricular pressure energy (EW) were determined pre, during and post light intensity cycle ergometry. Results: During exercise, despite a similar heart rate and blood pressure, patients had comparatively greater EW (P=0.03) and trend towards greater AIx (P=0.07) than controls. Exercise EW was greatest in patients with CF related diabetes (n=11). In all subjects, exercise EW was related to age (r=0.54, P<0.001) and FEV1% predicted (r=-0.32, P=0.01). Conclusions: Adults with CF have an abnormal haemodynamic response to exercise. This finding has deleterious implications for myocardial performance.

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