The effect of levodopa on vowel articulation in Parkinson's disease

a cross-linguistic study

Jidde Jacobi, Teja Rebernik, Roel Jonkers (Contributor), Michael Proctor (Contributor), Ben Maassen (Contributor), Martijn Wieling (Contributor)

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contribution

Abstract

Parkinson's disease (PD) is a neurological disorder that is characterized by a decay in global motor performance, manifest in tremor, abnormal gait, and dysarthria. PD dysarthria characteristics include monoloudness, pathological voice quality, and imprecise articulation. Standard treatment for relieving PD symptoms is the drug levodopa, but it is currently unknown how it affects speech. We investigated the effect of levodopa on the vowel space of 4 Dutch and 6 Slovenian PD participants. They recorded their speech on twenty occasions distributed over four days across 2-4 weeks. First and second formants of corner vowels [i-a-u] produced in isolated words were measured at acoustic midpoints of 4043 tokens. A vowel articulation index (VAI), a metric of vowel space dispersion,
was calculated for each speaker. VAI was not significantly affected by levodopa in either language, which may indicate that the motor control underlying vowel articulation is not as sensitive to levodopa as other motor symptoms.
Original languageEnglish
Title of host publicationProceedings of the 19th International Congress of Phonetic Sciences
Subtitle of host publicationICPhS2019
EditorsSasha Calhoun, Paola Escudero, Marija Tabain, Paul Warren
Place of PublicationCanberra
PublisherAustralasian Speech Science and Technology Association (ASSTA)
Pages1069-1073
Number of pages5
ISBN (Print)9780646800691
Publication statusPublished - 2019
EventInternational Congress of Phonetic Sciences (19th : 2019) - Melbourne, Australia
Duration: 5 Aug 20199 Aug 2019

Conference

ConferenceInternational Congress of Phonetic Sciences (19th : 2019)
Abbreviated titleICPhS2019
CountryAustralia
CityMelbourne
Period5/08/199/08/19

Keywords

  • Parkinson's disease
  • vowel production
  • levodopa
  • dysarthria
  • vowel acoustics

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    Jacobi, J., Rebernik, T., Jonkers, R., Proctor, M., Maassen, B., & Wieling, M. (2019). The effect of levodopa on vowel articulation in Parkinson's disease: a cross-linguistic study. In S. Calhoun, P. Escudero, M. Tabain, & P. Warren (Eds.), Proceedings of the 19th International Congress of Phonetic Sciences: ICPhS2019 (pp. 1069-1073). Canberra: Australasian Speech Science and Technology Association (ASSTA).