The effect of levodopa on vowel articulation in Parkinson's disease: a cross-linguistic study

Jidde Jacobi; Teja  Rebernik; Roel Jonkers; Michael Proctor; Ben Maassen; Martijn Wieling

The effect of levodopa on vowel articulation in Parkinson's disease: a cross-linguistic study

Jidde Jacobi, Teja Rebernik, Roel Jonkers (Contributor), Michael Proctor (Contributor), Ben Maassen (Contributor), Martijn Wieling (Contributor)

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

Abstract

Parkinson's disease (PD) is a neurological disorder that is characterized by a decay in global motor performance, manifest in tremor, abnormal gait, and dysarthria. PD dysarthria characteristics include monoloudness, pathological voice quality, and imprecise articulation. Standard treatment for relieving PD symptoms is the drug levodopa, but it is currently unknown how it affects speech. We investigated the effect of levodopa on the vowel space of 4 Dutch and 6 Slovenian PD participants. They recorded their speech on twenty occasions distributed over four days across 2-4 weeks. First and second formants of corner vowels [i-a-u] produced in isolated words were measured at acoustic midpoints of 4043 tokens. A vowel articulation index (VAI), a metric of vowel space dispersion,
was calculated for each speaker. VAI was not significantly affected by levodopa in either language, which may indicate that the motor control underlying vowel articulation is not as sensitive to levodopa as other motor symptoms.

Original language	English
Title of host publication	Proceedings of the 19th International Congress of Phonetic Sciences
Subtitle of host publication	ICPhS2019
Editors	Sasha Calhoun, Paola Escudero, Marija Tabain, Paul Warren
Place of Publication	Canberra
Publisher	Australasian Speech Science and Technology Association (ASSTA)
Pages	1069-1073
Number of pages	5
ISBN (Print)	9780646800691
Publication status	Published - 2019
Event	International Congress of Phonetic Sciences (19th : 2019) - Melbourne, Australia Duration: 5 Aug 2019 → 9 Aug 2019

Conference

Conference	International Congress of Phonetic Sciences (19th : 2019)
Abbreviated title	ICPhS2019
Country/Territory	Australia
City	Melbourne
Period	5/08/19 → 9/08/19

Keywords

Parkinson's disease
vowel production
levodopa
dysarthria
vowel acoustics

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http://www.assta.org/proceedings/ICPhS2019/papers/ICPhS_1118.pdfLicence: Unspecified

Cite this

Jacobi, J., Rebernik, T., Jonkers, R., Proctor, M., Maassen, B., & Wieling, M. (2019). The effect of levodopa on vowel articulation in Parkinson's disease: a cross-linguistic study. In S. Calhoun, P. Escudero, M. Tabain, & P. Warren (Eds.), Proceedings of the 19th International Congress of Phonetic Sciences: ICPhS2019 (pp. 1069-1073). Australasian Speech Science and Technology Association (ASSTA). http://www.assta.org/proceedings/ICPhS2019/papers/ICPhS_1118.pdf

Jacobi, Jidde ; Rebernik, Teja ; Jonkers, Roel et al. / The effect of levodopa on vowel articulation in Parkinson's disease : a cross-linguistic study. Proceedings of the 19th International Congress of Phonetic Sciences: ICPhS2019. editor / Sasha Calhoun ; Paola Escudero ; Marija Tabain ; Paul Warren. Canberra : Australasian Speech Science and Technology Association (ASSTA), 2019. pp. 1069-1073

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title = "The effect of levodopa on vowel articulation in Parkinson's disease: a cross-linguistic study",

abstract = "Parkinson's disease (PD) is a neurological disorder that is characterized by a decay in global motor performance, manifest in tremor, abnormal gait, and dysarthria. PD dysarthria characteristics include monoloudness, pathological voice quality, and imprecise articulation. Standard treatment for relieving PD symptoms is the drug levodopa, but it is currently unknown how it affects speech. We investigated the effect of levodopa on the vowel space of 4 Dutch and 6 Slovenian PD participants. They recorded their speech on twenty occasions distributed over four days across 2-4 weeks. First and second formants of corner vowels [i-a-u] produced in isolated words were measured at acoustic midpoints of 4043 tokens. A vowel articulation index (VAI), a metric of vowel space dispersion,was calculated for each speaker. VAI was not significantly affected by levodopa in either language, which may indicate that the motor control underlying vowel articulation is not as sensitive to levodopa as other motor symptoms.",

keywords = "Parkinson's disease, vowel production, levodopa, dysarthria, vowel acoustics",

author = "Jidde Jacobi and Teja Rebernik and Roel Jonkers and Michael Proctor and Ben Maassen and Martijn Wieling",

year = "2019",

language = "English",

isbn = "9780646800691",

pages = "1069--1073",

editor = "Calhoun, {Sasha } and Paola Escudero and Tabain, {Marija } and Paul Warren",

booktitle = "Proceedings of the 19th International Congress of Phonetic Sciences",

publisher = "Australasian Speech Science and Technology Association (ASSTA)",

note = "International Congress of Phonetic Sciences (19th : 2019), ICPhS2019 ; Conference date: 05-08-2019 Through 09-08-2019",

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Jacobi, J, Rebernik, T, Jonkers, R, Proctor, M, Maassen, B & Wieling, M 2019, The effect of levodopa on vowel articulation in Parkinson's disease: a cross-linguistic study. in S Calhoun, P Escudero, M Tabain & P Warren (eds), Proceedings of the 19th International Congress of Phonetic Sciences: ICPhS2019. Australasian Speech Science and Technology Association (ASSTA), Canberra, pp. 1069-1073, International Congress of Phonetic Sciences (19th : 2019), Melbourne, Victoria, Australia, 5/08/19. <http://www.assta.org/proceedings/ICPhS2019/papers/ICPhS_1118.pdf>

The effect of levodopa on vowel articulation in Parkinson's disease: a cross-linguistic study. / Jacobi, Jidde; Rebernik, Teja ; Jonkers, Roel (Contributor) et al.
Proceedings of the 19th International Congress of Phonetic Sciences: ICPhS2019. ed. / Sasha Calhoun; Paola Escudero; Marija Tabain; Paul Warren. Canberra: Australasian Speech Science and Technology Association (ASSTA), 2019. p. 1069-1073.

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

TY - GEN

T1 - The effect of levodopa on vowel articulation in Parkinson's disease

T2 - International Congress of Phonetic Sciences (19th : 2019)

AU - Jacobi, Jidde

AU - Rebernik, Teja

A2 - Jonkers, Roel

A2 - Proctor, Michael

A2 - Maassen, Ben

A2 - Wieling, Martijn

A2 - Calhoun, Sasha

A2 - Escudero, Paola

A2 - Tabain, Marija

A2 - Warren, Paul

PY - 2019

Y1 - 2019

N2 - Parkinson's disease (PD) is a neurological disorder that is characterized by a decay in global motor performance, manifest in tremor, abnormal gait, and dysarthria. PD dysarthria characteristics include monoloudness, pathological voice quality, and imprecise articulation. Standard treatment for relieving PD symptoms is the drug levodopa, but it is currently unknown how it affects speech. We investigated the effect of levodopa on the vowel space of 4 Dutch and 6 Slovenian PD participants. They recorded their speech on twenty occasions distributed over four days across 2-4 weeks. First and second formants of corner vowels [i-a-u] produced in isolated words were measured at acoustic midpoints of 4043 tokens. A vowel articulation index (VAI), a metric of vowel space dispersion,was calculated for each speaker. VAI was not significantly affected by levodopa in either language, which may indicate that the motor control underlying vowel articulation is not as sensitive to levodopa as other motor symptoms.

AB - Parkinson's disease (PD) is a neurological disorder that is characterized by a decay in global motor performance, manifest in tremor, abnormal gait, and dysarthria. PD dysarthria characteristics include monoloudness, pathological voice quality, and imprecise articulation. Standard treatment for relieving PD symptoms is the drug levodopa, but it is currently unknown how it affects speech. We investigated the effect of levodopa on the vowel space of 4 Dutch and 6 Slovenian PD participants. They recorded their speech on twenty occasions distributed over four days across 2-4 weeks. First and second formants of corner vowels [i-a-u] produced in isolated words were measured at acoustic midpoints of 4043 tokens. A vowel articulation index (VAI), a metric of vowel space dispersion,was calculated for each speaker. VAI was not significantly affected by levodopa in either language, which may indicate that the motor control underlying vowel articulation is not as sensitive to levodopa as other motor symptoms.

KW - Parkinson's disease

KW - vowel production

KW - levodopa

KW - dysarthria

KW - vowel acoustics

UR - http://www.assta.org/proceedings/ICPhS2019/

M3 - Conference proceeding contribution

SN - 9780646800691

SP - 1069

EP - 1073

BT - Proceedings of the 19th International Congress of Phonetic Sciences

PB - Australasian Speech Science and Technology Association (ASSTA)

CY - Canberra

Y2 - 5 August 2019 through 9 August 2019

ER -

Jacobi J, Rebernik T, Jonkers R, Proctor M, Maassen B, Wieling M. The effect of levodopa on vowel articulation in Parkinson's disease: a cross-linguistic study. In Calhoun S, Escudero P, Tabain M, Warren P, editors, Proceedings of the 19th International Congress of Phonetic Sciences: ICPhS2019. Canberra: Australasian Speech Science and Technology Association (ASSTA). 2019. p. 1069-1073

The effect of levodopa on vowel articulation in Parkinson's disease: a cross-linguistic study

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