The effects of free radical scavengers on arachidonic acid metabolism by ovine placental microsomes

G. E. Rice; M. S. Baker

doi:10.1016/0306-3623(91)90586-U

The effects of free radical scavengers on arachidonic acid metabolism by ovine placental microsomes

G. E. Rice^*, M. S. Baker

^*Corresponding author for this work

Research output: Contribution to journal › Article

1 Citation (Scopus)

Abstract

1. The effect of free radical (superoxide and hydroxyl) and hydrogen peroxide scavengers on the formation of prostaglandin E₂ by ovine placental microsomes was investigated. 2. Of the free radical scavengers tested only Mn Desferal, a low molecular weight (712 Da) superoxide scavenger, at concentrations of 0.5-5 mmol/1 significantly (P < 0.001) stimulated PGE₂ formation by ovine placental microsomes. 3. This observation is consistent with the involvement of superoxide radicals in the inactivation of prostaglandin G/H synthase (PGHS). 4. The results obtained further suggest that if superoxide radicals are important regulators of PGHS activity in the ovine placenta, they are not accessible to large molecular weight free radical scavengers.

Original language	English
Pages (from-to)	1109-1113
Number of pages	5
Journal	General Pharmacology
Volume	22
Issue number	6
DOIs	https://doi.org/10.1016/0306-3623(91)90586-U
Publication status	Published - 1991
Externally published	Yes

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Rice, G. E., & Baker, M. S. (1991). The effects of free radical scavengers on arachidonic acid metabolism by ovine placental microsomes. General Pharmacology, 22(6), 1109-1113. https://doi.org/10.1016/0306-3623(91)90586-U

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abstract = "1. The effect of free radical (superoxide and hydroxyl) and hydrogen peroxide scavengers on the formation of prostaglandin E2 by ovine placental microsomes was investigated. 2. Of the free radical scavengers tested only Mn Desferal, a low molecular weight (712 Da) superoxide scavenger, at concentrations of 0.5-5 mmol/1 significantly (P < 0.001) stimulated PGE2 formation by ovine placental microsomes. 3. This observation is consistent with the involvement of superoxide radicals in the inactivation of prostaglandin G/H synthase (PGHS). 4. The results obtained further suggest that if superoxide radicals are important regulators of PGHS activity in the ovine placenta, they are not accessible to large molecular weight free radical scavengers.",

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N2 - 1. The effect of free radical (superoxide and hydroxyl) and hydrogen peroxide scavengers on the formation of prostaglandin E2 by ovine placental microsomes was investigated. 2. Of the free radical scavengers tested only Mn Desferal, a low molecular weight (712 Da) superoxide scavenger, at concentrations of 0.5-5 mmol/1 significantly (P < 0.001) stimulated PGE2 formation by ovine placental microsomes. 3. This observation is consistent with the involvement of superoxide radicals in the inactivation of prostaglandin G/H synthase (PGHS). 4. The results obtained further suggest that if superoxide radicals are important regulators of PGHS activity in the ovine placenta, they are not accessible to large molecular weight free radical scavengers.

AB - 1. The effect of free radical (superoxide and hydroxyl) and hydrogen peroxide scavengers on the formation of prostaglandin E2 by ovine placental microsomes was investigated. 2. Of the free radical scavengers tested only Mn Desferal, a low molecular weight (712 Da) superoxide scavenger, at concentrations of 0.5-5 mmol/1 significantly (P < 0.001) stimulated PGE2 formation by ovine placental microsomes. 3. This observation is consistent with the involvement of superoxide radicals in the inactivation of prostaglandin G/H synthase (PGHS). 4. The results obtained further suggest that if superoxide radicals are important regulators of PGHS activity in the ovine placenta, they are not accessible to large molecular weight free radical scavengers.

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