The enigma of the CLIC proteins

Ion channels, redox proteins, enzymes, scaffolding proteins?

Dene R. Littler, Stephen J. Harrop, Sophia C. Goodchild, Juanita M. Phang, Andrew V. Mynott, Lele Jiang, Stella M. Valenzuela, Michele Mazzanti, Louise J. Brown, Samuel N. Breit, Paul M G Curmi*

*Corresponding author for this work

Research output: Contribution to journalReview article

98 Citations (Scopus)

Abstract

Chloride intracellular channel proteins (CLICs) are distinct from most ion channels in that they have both soluble and integral membrane forms. CLICs are highly conserved in chordates, with six vertebrate paralogues. CLIC-like proteins are found in other metazoans. CLICs form channels in artificial bilayers in a process favoured by oxidising conditions and low pH. They are structurally plastic, with CLIC1 adopting two distinct soluble conformations. Phylogenetic and structural data indicate that CLICs are likely to have enzymatic function. The physiological role of CLICs appears to be maintenance of intracellular membranes, which is associated with tubulogenesis but may involve other substructures.

Original languageEnglish
Pages (from-to)2093-2101
Number of pages9
JournalFEBS Letters
Volume584
Issue number10
DOIs
Publication statusPublished - May 2010

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    Littler, D. R., Harrop, S. J., Goodchild, S. C., Phang, J. M., Mynott, A. V., Jiang, L., ... Curmi, P. M. G. (2010). The enigma of the CLIC proteins: Ion channels, redox proteins, enzymes, scaffolding proteins? FEBS Letters, 584(10), 2093-2101. https://doi.org/10.1016/j.febslet.2010.01.027