The evolution of new catalytic mechanisms for xenobiotic hydrolysis in bacterial metalloenzymes

Elena Sugrue, Carol J. Hartley, Colin Scott, Colin J. Jackson*

*Corresponding author for this work

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

An increasing number of bacterial metalloenzymes have been shown to catalyse the breakdown of xenobiotics in the environment, while others exhibit a variety of promiscuous xenobiotic-degrading activities. Several different evolutionary processes have allowed these enzymes to gain or enhance xenobiotic-degrading activity. In this review, we have surveyed the range of xenobiotic-degrading metalloenzymes, and discuss the molecular and catalytic basis for the development of new activities. We also highlight how our increased understanding of the natural evolution of xenobiotic-degrading metalloenzymes can be been applied to laboratory enzyme design.

Original languageEnglish
Pages (from-to)1383-1395
Number of pages13
JournalAustralian Journal of Chemistry
Volume69
Issue number12
DOIs
Publication statusPublished - 2016
Externally publishedYes

Fingerprint Dive into the research topics of 'The evolution of new catalytic mechanisms for xenobiotic hydrolysis in bacterial metalloenzymes'. Together they form a unique fingerprint.

Cite this