The Filling Mechanism

Marcus Stoodley*

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

    11 Citations (Scopus)


    Elucidating the syrinx filling mechanism is the holy grail of clinicians and researchers studying this enigmatic disease. This chapter critically appraises the plethora of historical and current theories which have attempted to explain the pathophysiology of syringomyelia. The author also reviews current knowledge on syrinx fluid composition and pressure and hydrodynamic mechanisms and discusses other possible causes of fluid collection including tumours, interstitial fluid, blood-spinal cord barrier disruption, and the role of aquaporins.

    Original languageEnglish
    Title of host publicationSyringomyelia
    Subtitle of host publicationA Disorder of CSF Circulation
    EditorsGraham Flint, Clare Rusbridge
    Place of PublicationHeidelberg
    PublisherSpringer, Springer Nature
    Number of pages16
    ISBN (Electronic)9783642137068
    ISBN (Print)9783540724841
    Publication statusPublished - 2014


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