The first case report of Schnitzler Syndrome presenting with eye pain

Richard R. Sadig*, D. Wakefield, C. L. Fraser

*Corresponding author for this work

Research output: Contribution to journalLetterpeer-review


Schnitzler syndrome is a rare, auto inflammatory condition known to manifest with bone pain, urticarial rash, fevers, relapsing arthralgia, and fatigue. In this case report, we describe a patient who was diagnosed with Schnitzler Syndrome that had initially presented with a unilateral pressure-type headache with a sensation of a ‘dagger’ stabbing into the back of the eye. He also had an associated ipsilateral redness of the conjunctiva, eyelid swelling, subtle optic disc elevations bilaterally and facial flushing - but with no visual acuity, pupillary, or lacrimatory changes. Anterior segment, fundoscopy, intraocular pressures and extraocular muscle movements were otherwise normal.

Original languageEnglish
Pages (from-to)175-177
Number of pages3
JournalOcular Immunology and Inflammation
Issue number2
Early online date22 Feb 2019
Publication statusPublished - Feb 2020
Externally publishedYes


  • Autonomic cephalgia
  • disc elevation
  • eye pain
  • injected conjunctivae
  • ophthalmology
  • Schnitzler


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