The functional role of human right hippocampal/parahippocampal theta rhythm in environmental encoding during virtual spatial navigation

Yi Pu*, Brian R. Cornwell, Douglas Cheyne, Blake W. Johnson

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    16 Citations (Scopus)

    Abstract

    Low frequency theta band oscillations (4–8 Hz) are thought to provide a timing mechanism for hippocampal place cell firing and to mediate the formation of spatial memory. In rodents, hippocampal theta has been shown to play an important role in encoding a new environment during spatial navigation, but a similar functional role of hippocampal theta in humans has not been firmly established. To investigate this question, we recorded healthy participants’ brain responses with a 160-channel whole-head MEG system as they performed two training sets of a virtual Morris water maze task. Environment layouts (except for platform locations) of the two sets were kept constant to measure theta activity during spatial learning in new and familiar environments. In line with previous findings, left hippocampal/parahippocampal theta showed more activation navigating to a hidden platform relative to random swimming. Consistent with our hypothesis, right hippocampal/parahippocampal theta was stronger during the first training set compared to the second one. Notably, theta in this region during the first training set correlated with spatial navigation performance across individuals in both training sets. These results strongly argue for the functional importance of right hippocampal theta in initial encoding of configural properties of an environment during spatial navigation. Our findings provide important evidence that right hippocampal/parahippocampal theta activity is associated with environmental encoding in the human brain. Hum Brain Mapp 38:1347–1361, 2017.

    Original languageEnglish
    Pages (from-to)1347-1361
    Number of pages15
    JournalHuman Brain Mapping
    Volume38
    Issue number3
    DOIs
    Publication statusPublished - 1 Mar 2017

    Keywords

    • hippocampus
    • magnetoencephalography
    • spatial navigation
    • theta rhythm
    • virtual reality

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