The genome of the natural genetic engineer Agrobacterium tumefaciens C58

D. W. Wood, J. C. Setubal, R. Kaul, D. E. Monks, J. P. Kitajima, V. K. Okura, Y. Zhou, L. Chen, G. E. Wood, Jr Almeida, L. Woo, Y. Chen, I. T. Paulsen, J. A. Eisen, P. D. Karp, Sr Bovee D., P. Chapman, J. Clendenning, G. Deatherage, W. Gillet & 31 others C. Grant, T. Kutyavin, R. Levy, M. J. Li, E. McClelland, A. Palmieri, C. Raymond, G. Rouse, C. Saenphimmachak, Z. Wu, P. Romero, D. Gordon, S. Zhang, H. Yoo, Y. Tao, P. Biddle, M. Jung, W. Krespan, M. Perry, B. Gordon-Kamm, L. Liao, S. Kim, C. Hendrick, Z. Y. Zhao, M. Dolan, F. Chumley, S. V. Tingey, J. F. Tomb, M. P. Gordon, M. V. Olson, E. W. Nester*

*Corresponding author for this work

Research output: Contribution to journalArticle

568 Citations (Scopus)

Abstract

The 5.67-megabase genome of the plant pathogen Agrobacterium tumefaciens C58 consists of a circular chromosome, a linear chromosome, and two plasmids. Extensive orthology and nucleotide colinearity between the genomes of A. tumefaciens and the plant symbiont Sinorhizobium meliloti suggest a recent evolutionary divergence. Their similarities include metabolic, transport, and regulatory systems that promote survival in the highly competitive rhizosphere; differences are apparent in their genome structure and virulence gene complement. Availability of the A. tumefaciens sequence will facilitate investigations into the molecular basis of pathogenesis and the evolutionary divergence of pathogenic and symbiotic lifestyles.

Original languageEnglish
Pages (from-to)2317-2323
Number of pages7
JournalScience
Volume294
Issue number5550
DOIs
Publication statusPublished - 14 Dec 2001
Externally publishedYes

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    Wood, D. W., Setubal, J. C., Kaul, R., Monks, D. E., Kitajima, J. P., Okura, V. K., ... Nester, E. W. (2001). The genome of the natural genetic engineer Agrobacterium tumefaciens C58. Science, 294(5550), 2317-2323. https://doi.org/10.1126/science.1066804