The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough

John F. Heidelberg*, Rekha Seshadri, Shelley A. Haveman, Christopher L. Hemme, Ian T. Paulsen, James F. Kolonay, Jonathan A. Eisen, Naomi Ward, Barbara Methe, Lauren M. Brinkac, Sean C. Daugherty, Robert T. Deboy, Robert J. Dodson, A. Scott Durkin, Ramana Madupu, William C. Nelson, Steven A. Sullivan, Derrick Fouts, Daniel H. Haft, Jeremy Selengut & 15 others Jeremy D. Peterson, Tanja M. Davidsen, Nikhat Zafar, Liwei Zhou, Diana Radune, George Dimitrov, Mark Hance, Kevin Tran, Hoda Khouri, John Gill, Terry R. Utterback, Tamara V. Feldblyum, Judy D. Wall, Gerrit Voordouw, Claire M. Fraser

*Corresponding author for this work

Research output: Contribution to journalArticle

407 Citations (Scopus)

Abstract

Desulfovibrio vulgaris Hildenborough is a model organism for studying the energy metabolism of sulfate-reducing bacteria (SRB) and for understanding the economic impacts of SRB, including biocorrosion of metal infrastructure and bioremediation of toxic metal ions. The 3,570,858 base pair (bp) genome sequence reveals a network of novel c-type cytochromes, connecting multiple periplasmic hydrogenases and formate dehydrogenases, as a key feature of its energy metabolism. The relative arrangement of genes encoding enzymes for energy transduction, together with inferred cellular location of the enzymes, provides a basis for proposing an expansion to the 'hydrogen-cycling' model for increasing energy efficiency in this bacterium. Plasmid-encoded functions include modification of cell surface components, nitrogen fixation and a type-III protein secretion system. This genome sequence represents a substantial step toward the elucidation of pathways for reduction (and bioremediation) of pollutants such as uranium and chromium and offers a new starting point for defining this organism's complex anaerobic respiration.

Original languageEnglish
Pages (from-to)554-559
Number of pages6
JournalNature Biotechnology
Volume22
Issue number5
DOIs
Publication statusPublished - May 2004
Externally publishedYes

Fingerprint Dive into the research topics of 'The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough'. Together they form a unique fingerprint.

Cite this