The gramicidin A channel

comparison of the energy profiles of Na+, K+ and Cs+. Influence of the flexibility of the ethanolamine end chain on the profiles

Catherine Etchebest*, Shoba Ranganathan, Alberte Pullman

*Corresponding author for this work

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The energy profiles for single occupancy by Cs+ and Na+ in the gramicidin A channel assumed to be in a head-to-head β6.33.3 helical dimeric structure, were computed: (A) allowing complete conformational freedom to the ethanolamine end, (B) constraining it to stay in its intrinsically preferred conformation. Whatever the constraint, both the entrance barrier and the central barrier appear in the order Cs+< K+< Na+. Introducing the flexibility of the tail modifies appreciably the profiles and the location of the extrema along it. Energy profile Gramicidin A Ethanolamine end Caesium Potassium Sodium Energy barrier Theoretical computation.

Original languageEnglish
Pages (from-to)301-306
Number of pages6
JournalFEBS Letters
Volume173
Issue number2
DOIs
Publication statusPublished - 6 Aug 1984
Externally publishedYes

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