TY - JOUR
T1 - The gramicidin A channel
T2 - comparison of the energy profiles of Na+, K+ and Cs+. Influence of the flexibility of the ethanolamine end chain on the profiles
AU - Etchebest, Catherine
AU - Ranganathan, Shoba
AU - Pullman, Alberte
PY - 1984/8/6
Y1 - 1984/8/6
N2 - The energy profiles for single occupancy by Cs+ and Na+ in the gramicidin A channel assumed to be in a head-to-head β6.33.3 helical dimeric structure, were computed: (A) allowing complete conformational freedom to the ethanolamine end, (B) constraining it to stay in its intrinsically preferred conformation. Whatever the constraint, both the entrance barrier and the central barrier appear in the order Cs+< K+< Na+. Introducing the flexibility of the tail modifies appreciably the profiles and the location of the extrema along it. Energy profile Gramicidin A Ethanolamine end Caesium Potassium Sodium Energy barrier Theoretical computation.
AB - The energy profiles for single occupancy by Cs+ and Na+ in the gramicidin A channel assumed to be in a head-to-head β6.33.3 helical dimeric structure, were computed: (A) allowing complete conformational freedom to the ethanolamine end, (B) constraining it to stay in its intrinsically preferred conformation. Whatever the constraint, both the entrance barrier and the central barrier appear in the order Cs+< K+< Na+. Introducing the flexibility of the tail modifies appreciably the profiles and the location of the extrema along it. Energy profile Gramicidin A Ethanolamine end Caesium Potassium Sodium Energy barrier Theoretical computation.
UR - http://www.scopus.com/inward/record.url?scp=0021173195&partnerID=8YFLogxK
U2 - 10.1016/0014-5793(84)80795-4
DO - 10.1016/0014-5793(84)80795-4
M3 - Article
C2 - 6204889
AN - SCOPUS:0021173195
SN - 0014-5793
VL - 173
SP - 301
EP - 306
JO - FEBS Letters
JF - FEBS Letters
IS - 2
ER -