TY - JOUR
T1 - The gut microbiota and mental health in adults
AU - Järbrink-Sehgal, Ellionore
AU - Andreasson, Anna
N1 - Copyright the Author(s) 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.
PY - 2020/6
Y1 - 2020/6
N2 - A growing body of evidence point toward the bidirectional gut microbiota–brain axis playing a role in mental health. Most of this research is conducted on animals why we in this review summarize and comment upon recent studies evaluating the gut microbiome in mental health in humans. Further support for the relevance of the bidirectional gut microbiota–brain communication in mood disorders has been presented, such as the effect of probiotics on brain connectivity and mental health outcomes and pregnancy related stress on gut microbiota in the newborn child. However, the heterogeneity between studies precludes conclusions regarding differences in microbiota composition in mental disease and health and many of the studies are limited by a cross-sectional design, small sample sizes and multiple comparisons. Thus, well-designed longitudinal studies with larger sample size, accounting for confounders are needed.
AB - A growing body of evidence point toward the bidirectional gut microbiota–brain axis playing a role in mental health. Most of this research is conducted on animals why we in this review summarize and comment upon recent studies evaluating the gut microbiome in mental health in humans. Further support for the relevance of the bidirectional gut microbiota–brain communication in mood disorders has been presented, such as the effect of probiotics on brain connectivity and mental health outcomes and pregnancy related stress on gut microbiota in the newborn child. However, the heterogeneity between studies precludes conclusions regarding differences in microbiota composition in mental disease and health and many of the studies are limited by a cross-sectional design, small sample sizes and multiple comparisons. Thus, well-designed longitudinal studies with larger sample size, accounting for confounders are needed.
UR - http://www.scopus.com/inward/record.url?scp=85080994683&partnerID=8YFLogxK
U2 - 10.1016/j.conb.2020.01.016
DO - 10.1016/j.conb.2020.01.016
M3 - Article
C2 - 32163822
AN - SCOPUS:85080994683
VL - 62
SP - 102
EP - 114
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
SN - 0959-4388
ER -