The Hierarchical Taxonomy of Psychopathology (HiTOP): a quantitative nosology based on consensus of evidence

Roman Kotov; Robert F. Krueger; David Watson; David C. Cicero; Christopher C. Conway; Colin G. Deyoung; Nicholas R. Eaton; Miriam K. Forbes; Michael N. Hallquist; Robert D. Latzman; Stephanie N. Mullins-Sweatt; Camilo J. Ruggero; Leonard J. Simms; Irwin D. Waldman; Monika A. Waszczuk; Aidan G.C. Wright

doi:10.1146/annurev-clinpsy-081219-093304

The Hierarchical Taxonomy of Psychopathology (HiTOP): a quantitative nosology based on consensus of evidence

Roman Kotov, Robert F. Krueger, David Watson, David C. Cicero, Christopher C. Conway, Colin G. Deyoung, Nicholas R. Eaton, Miriam K. Forbes, Michael N. Hallquist, Robert D. Latzman, Stephanie N. Mullins-Sweatt, Camilo J. Ruggero, Leonard J. Simms, Irwin D. Waldman, Monika A. Waszczuk, Aidan G.C. Wright

Centre for Emotional Health (CEH)

Research output: Contribution to journal › Review article › peer-review

113 Citations (Scopus)

Abstract

Traditional diagnostic systems went beyond empirical evidence on the structure of mental health. Consequently, these diagnoses do not depict psychopathology accurately, and their validity in research and utility in clinicalpractice are therefore limited. The Hierarchical Taxonomy of Psychopathology (HiTOP) consortium proposed a model based on structural evidence. It addresses problems of diagnostic heterogeneity, comorbidity, and unreliability. We review the HiTOP model, supporting evidence, and conceptualization of psychopathology in this hierarchical dimensional framework. The system is not yet comprehensive, and we describe the processes for improving and expanding it. We summarize data on the ability of HiTOP to predict and explain etiology (genetic, environmental, and neurobiological), risk factors, outcomes, and treatment response. We describe progress in the development of HiTOP-based measures and in clinical implementation of the system. Finally, we review outstanding challenges and the research agenda. HiTOP is of practical utility already, and its ongoing development will produce a transformative map of psychopathology.

Original language	English
Pages (from-to)	83-108
Number of pages	26
Journal	Annual Review of Clinical Psychology
Volume	17
DOIs	https://doi.org/10.1146/annurev-clinpsy-081219-093304
Publication status	Published - 7 May 2021

Keywords

internalizing
externalizing
factor analysis
structure
classification
nosology

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10.1146/annurev-clinpsy-081219-093304

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Kotov, R., Krueger, R. F., Watson, D., Cicero, D. C., Conway, C. C., Deyoung, C. G., Eaton, N. R., Forbes, M. K., Hallquist, M. N., Latzman, R. D., Mullins-Sweatt, S. N., Ruggero, C. J., Simms, L. J., Waldman, I. D., Waszczuk, M. A., & Wright, A. G. C. (2021). The Hierarchical Taxonomy of Psychopathology (HiTOP): a quantitative nosology based on consensus of evidence. Annual Review of Clinical Psychology, 17, 83-108. https://doi.org/10.1146/annurev-clinpsy-081219-093304

Kotov, Roman ; Krueger, Robert F. ; Watson, David ; Cicero, David C. ; Conway, Christopher C. ; Deyoung, Colin G. ; Eaton, Nicholas R. ; Forbes, Miriam K. ; Hallquist, Michael N. ; Latzman, Robert D. ; Mullins-Sweatt, Stephanie N. ; Ruggero, Camilo J. ; Simms, Leonard J. ; Waldman, Irwin D. ; Waszczuk, Monika A. ; Wright, Aidan G.C. / The Hierarchical Taxonomy of Psychopathology (HiTOP) : a quantitative nosology based on consensus of evidence. In: Annual Review of Clinical Psychology. 2021 ; Vol. 17. pp. 83-108.

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title = "The Hierarchical Taxonomy of Psychopathology (HiTOP): a quantitative nosology based on consensus of evidence",

abstract = "Traditional diagnostic systems went beyond empirical evidence on the structure of mental health. Consequently, these diagnoses do not depict psychopathology accurately, and their validity in research and utility in clinicalpractice are therefore limited. The Hierarchical Taxonomy of Psychopathology (HiTOP) consortium proposed a model based on structural evidence. It addresses problems of diagnostic heterogeneity, comorbidity, and unreliability. We review the HiTOP model, supporting evidence, and conceptualization of psychopathology in this hierarchical dimensional framework. The system is not yet comprehensive, and we describe the processes for improving and expanding it. We summarize data on the ability of HiTOP to predict and explain etiology (genetic, environmental, and neurobiological), risk factors, outcomes, and treatment response. We describe progress in the development of HiTOP-based measures and in clinical implementation of the system. Finally, we review outstanding challenges and the research agenda. HiTOP is of practical utility already, and its ongoing development will produce a transformative map of psychopathology.",

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author = "Roman Kotov and Krueger, {Robert F.} and David Watson and Cicero, {David C.} and Conway, {Christopher C.} and Deyoung, {Colin G.} and Eaton, {Nicholas R.} and Forbes, {Miriam K.} and Hallquist, {Michael N.} and Latzman, {Robert D.} and Mullins-Sweatt, {Stephanie N.} and Ruggero, {Camilo J.} and Simms, {Leonard J.} and Waldman, {Irwin D.} and Waszczuk, {Monika A.} and Wright, {Aidan G.C.}",

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Kotov, R, Krueger, RF, Watson, D, Cicero, DC, Conway, CC, Deyoung, CG, Eaton, NR, Forbes, MK, Hallquist, MN, Latzman, RD, Mullins-Sweatt, SN, Ruggero, CJ, Simms, LJ, Waldman, ID, Waszczuk, MA & Wright, AGC 2021, 'The Hierarchical Taxonomy of Psychopathology (HiTOP): a quantitative nosology based on consensus of evidence', Annual Review of Clinical Psychology, vol. 17, pp. 83-108. https://doi.org/10.1146/annurev-clinpsy-081219-093304

The Hierarchical Taxonomy of Psychopathology (HiTOP) : a quantitative nosology based on consensus of evidence. / Kotov, Roman; Krueger, Robert F.; Watson, David; Cicero, David C.; Conway, Christopher C.; Deyoung, Colin G.; Eaton, Nicholas R.; Forbes, Miriam K.; Hallquist, Michael N.; Latzman, Robert D.; Mullins-Sweatt, Stephanie N.; Ruggero, Camilo J.; Simms, Leonard J.; Waldman, Irwin D.; Waszczuk, Monika A.; Wright, Aidan G.C.

In: Annual Review of Clinical Psychology, Vol. 17, 07.05.2021, p. 83-108.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - The Hierarchical Taxonomy of Psychopathology (HiTOP)

T2 - a quantitative nosology based on consensus of evidence

AU - Kotov, Roman

AU - Krueger, Robert F.

AU - Watson, David

AU - Cicero, David C.

AU - Conway, Christopher C.

AU - Deyoung, Colin G.

AU - Eaton, Nicholas R.

AU - Forbes, Miriam K.

AU - Hallquist, Michael N.

AU - Latzman, Robert D.

AU - Mullins-Sweatt, Stephanie N.

AU - Ruggero, Camilo J.

AU - Simms, Leonard J.

AU - Waldman, Irwin D.

AU - Waszczuk, Monika A.

AU - Wright, Aidan G.C.

PY - 2021/5/7

Y1 - 2021/5/7

N2 - Traditional diagnostic systems went beyond empirical evidence on the structure of mental health. Consequently, these diagnoses do not depict psychopathology accurately, and their validity in research and utility in clinicalpractice are therefore limited. The Hierarchical Taxonomy of Psychopathology (HiTOP) consortium proposed a model based on structural evidence. It addresses problems of diagnostic heterogeneity, comorbidity, and unreliability. We review the HiTOP model, supporting evidence, and conceptualization of psychopathology in this hierarchical dimensional framework. The system is not yet comprehensive, and we describe the processes for improving and expanding it. We summarize data on the ability of HiTOP to predict and explain etiology (genetic, environmental, and neurobiological), risk factors, outcomes, and treatment response. We describe progress in the development of HiTOP-based measures and in clinical implementation of the system. Finally, we review outstanding challenges and the research agenda. HiTOP is of practical utility already, and its ongoing development will produce a transformative map of psychopathology.

AB - Traditional diagnostic systems went beyond empirical evidence on the structure of mental health. Consequently, these diagnoses do not depict psychopathology accurately, and their validity in research and utility in clinicalpractice are therefore limited. The Hierarchical Taxonomy of Psychopathology (HiTOP) consortium proposed a model based on structural evidence. It addresses problems of diagnostic heterogeneity, comorbidity, and unreliability. We review the HiTOP model, supporting evidence, and conceptualization of psychopathology in this hierarchical dimensional framework. The system is not yet comprehensive, and we describe the processes for improving and expanding it. We summarize data on the ability of HiTOP to predict and explain etiology (genetic, environmental, and neurobiological), risk factors, outcomes, and treatment response. We describe progress in the development of HiTOP-based measures and in clinical implementation of the system. Finally, we review outstanding challenges and the research agenda. HiTOP is of practical utility already, and its ongoing development will produce a transformative map of psychopathology.

KW - internalizing

KW - externalizing

KW - factor analysis

KW - structure

KW - classification

KW - nosology

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U2 - 10.1146/annurev-clinpsy-081219-093304

DO - 10.1146/annurev-clinpsy-081219-093304

M3 - Review article

C2 - 33577350

AN - SCOPUS:85101867124

VL - 17

SP - 83

EP - 108

JO - Annual Review of Clinical Psychology

JF - Annual Review of Clinical Psychology

SN - 1548-5943

ER -

The Hierarchical Taxonomy of Psychopathology (HiTOP): a quantitative nosology based on consensus of evidence

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Keywords

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