The human proteome project: Current state and future direction

Pierre Legrain*, Ruedi Aebersold, Alexander Archakov, Amos Bairoch, Kumar Bala, Laura Beretta, John Bergeron, Christoph H. Borchers, Garry L. Corthals, Catherine E. Costello, Eric W. Deutsch, Bruno Domon, William Hancock, Fuchu He, Denis Hochstrasser, György Marko-Varga, Ghasem Hosseini Salekdeh, Salvatore Sechi, Michael Snyder, Sudhir SrivastavaMathias Uhlén, Cathy H. Wu, Tadashi Yamamoto, Young Ki Paik, Gilbert S. Omenn

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    315 Citations (Scopus)


    After the successful completion of the Human Genome Project, the Human Proteome Organization has recently officially launched a global Human Proteome Project (HPP), which is designed to map the entire human protein set. Given the lack of protein-level evidence for about 30% of the estimated 20,300 protein-coding genes, a systematic global effort will be necessary to achieve this goal with respect to protein abundance, distribution, subcellular localization, interaction with other biomolecules, and functions at specific time points. As a general experimental strategy, HPP research groups will use the three working pillars for HPP: mass spectrometry, antibody capture, and bioinformatics tools and knowledge bases. The HPP participants will take advantage of the output and cross-analyses from the ongoing Human Proteome Organization initiatives and a chromosome-centric protein mapping strategy, termed C-HPP, with which many national teams are currently engaged. In addition, numerous biologically driven and disease-oriented projects will be stimulated and facilitated by the HPP. Timely planning with proper governance of HPP will deliver a protein parts list, reagents, and tools for protein studies and analyses, and a stronger basis for personalized medicine. The Human Proteome Organization urges each national research funding agency and the scientific community at large to identify their preferred pathways to participate in aspects of this highly promising project in a HPP consortium of funders and investigators.

    Original languageEnglish
    Pages (from-to)10.1074/mcp.M111.009993–1-10.1074/mcp.M111.009993–5
    Number of pages5
    JournalMolecular and Cellular Proteomics
    Issue number7
    Publication statusPublished - Jul 2011


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