The human systemic and cerebral circulations: contrasts in structure and function

Michael O'Rourke; Jonathan Stone; Audrey Adji; Mi Ok Kim; Yan Li; Ji Guang Wang; Alberto Avolio; Per Kristian Eide; Marek Czosnyka

doi:10.2991/artres.k.200704.001

The human systemic and cerebral circulations: contrasts in structure and function

Michael O'Rourke^*, Jonathan Stone, Audrey Adji, Mi Ok Kim, Yan Li, Ji Guang Wang, Alberto Avolio, Per Kristian Eide, Marek Czosnyka

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

6 Citations (Scopus)

67 Downloads (Pure)

Abstract

Apart from peculiarities of the cerebral circulation, required to perfuse the brain with the subject erect, the principles established for function of the human systemic circulation (pulsatile flow at input and steady flow at output in capillaries) are identical to those established for other mammals. Assumption of the erect posture first as Homo erectus, then as Homo sapiens, conferred huge advantage to humans and led to command of the mammalian kingdom. But this required a circulation which could perfuse the brain securely against gravity in all positions of the body. This review covers what presently is known about the human cerebral circulation, and how such knowledge can be applied in some clinical conditions including development of dementia in older subjects, and in management of patients with elevation of intra-cranial pressure in younger subjects.

Original language	English
Pages (from-to)	197-211
Number of pages	15
Journal	Artery Research
Volume	26
Issue number	4
DOIs	https://doi.org/10.2991/artres.k.200704.001
Publication status	Published - Dec 2020

Bibliographical note

Copyright the Publisher 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

Wave reflection
reflection coefficient
pressure waves
flow waves
intracranial pressure
pulse wave analysis
Wave reflection reflection coefficient pressure waves flow waves intracranial pressure pulse wave analysis

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10.2991/artres.k.200704.001Licence: CC BY-NC

Publisher version (open access)Final published version, 4.05 MBLicence: CC BY-NC

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title = "The human systemic and cerebral circulations: contrasts in structure and function",

abstract = "Apart from peculiarities of the cerebral circulation, required to perfuse the brain with the subject erect, the principles established for function of the human systemic circulation (pulsatile flow at input and steady flow at output in capillaries) are identical to those established for other mammals. Assumption of the erect posture first as Homo erectus, then as Homo sapiens, conferred huge advantage to humans and led to command of the mammalian kingdom. But this required a circulation which could perfuse the brain securely against gravity in all positions of the body. This review covers what presently is known about the human cerebral circulation, and how such knowledge can be applied in some clinical conditions including development of dementia in older subjects, and in management of patients with elevation of intra-cranial pressure in younger subjects.",

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author = "Michael O'Rourke and Jonathan Stone and Audrey Adji and Kim, {Mi Ok} and Yan Li and Wang, {Ji Guang} and Alberto Avolio and Eide, {Per Kristian} and Marek Czosnyka",

note = "Copyright the Publisher 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

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AU - Stone, Jonathan

AU - Adji, Audrey

AU - Kim, Mi Ok

AU - Li, Yan

AU - Wang, Ji Guang

AU - Avolio, Alberto

AU - Eide, Per Kristian

AU - Czosnyka, Marek

N1 - Copyright the Publisher 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2020/12

Y1 - 2020/12

N2 - Apart from peculiarities of the cerebral circulation, required to perfuse the brain with the subject erect, the principles established for function of the human systemic circulation (pulsatile flow at input and steady flow at output in capillaries) are identical to those established for other mammals. Assumption of the erect posture first as Homo erectus, then as Homo sapiens, conferred huge advantage to humans and led to command of the mammalian kingdom. But this required a circulation which could perfuse the brain securely against gravity in all positions of the body. This review covers what presently is known about the human cerebral circulation, and how such knowledge can be applied in some clinical conditions including development of dementia in older subjects, and in management of patients with elevation of intra-cranial pressure in younger subjects.

AB - Apart from peculiarities of the cerebral circulation, required to perfuse the brain with the subject erect, the principles established for function of the human systemic circulation (pulsatile flow at input and steady flow at output in capillaries) are identical to those established for other mammals. Assumption of the erect posture first as Homo erectus, then as Homo sapiens, conferred huge advantage to humans and led to command of the mammalian kingdom. But this required a circulation which could perfuse the brain securely against gravity in all positions of the body. This review covers what presently is known about the human cerebral circulation, and how such knowledge can be applied in some clinical conditions including development of dementia in older subjects, and in management of patients with elevation of intra-cranial pressure in younger subjects.

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KW - reflection coefficient

KW - pressure waves

KW - flow waves

KW - intracranial pressure

KW - pulse wave analysis

KW - Wave reflection reflection coefficient pressure waves flow waves intracranial pressure pulse wave analysis

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DO - 10.2991/artres.k.200704.001

M3 - Review article

SN - 1872-9312

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SP - 197

EP - 211

JO - Artery Research

JF - Artery Research

IS - 4

ER -

The human systemic and cerebral circulations: contrasts in structure and function

Abstract

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Keywords

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