The hypothalamus and autonomic regulation

an overview

Roger A. L. Dampney*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Citations (Scopus)

Abstract

The hypothalamus plays a key role in regulating autonomic function, usually as part of more generalized, often quite stereotyped, behavioural responses triggered by internal challenges (e.g., a change in body temperature or blood glucose levels) or external threats (e.g., the sight, sound or odour of a predator). Neurons within hypothalamic nuclei (especially the paraventricular nucleus, dorsomedial hypothalamus and perifornical area) make direct and indirect connections with sympathetic and parasympathetic preganglionic neurons and, in turn, receive inputs from a wide variety of sources, including (1) visceral and pain receptors, (2) receptors in circumventricular organs signalling changes in blood levels of circulating substances, and (3) inputs from the external environment, such as inputs signalling changes in temperature, light, and odour. Hypothalamic nuclei, especially the paraventricular nucleus and dorsomedial hypothalamus, are believed to generate the marked increases in sympathetic activity associated with disorders, such as neurogenic hypertension, severe heart failure and panic disorder.

Original languageEnglish
Title of host publicationCentral regulation of autonomic functions
EditorsIda J. Llewellyn-Smith, Anthony J.M. Verbene
Place of PublicationNew York, US
PublisherOxford University Press
Pages47-61
Number of pages14
Edition2
ISBN (Electronic)9780199894130
ISBN (Print)9780195306637
Publication statusPublished - 1 May 2011
Externally publishedYes

Keywords

  • Body temperature
  • Circumventricular organs
  • Defensive behaviour
  • Dorsomedial hypothalamus
  • Heart failure
  • Neurogenic hypertension
  • Paraventricular nucleus
  • Perifornical area
  • Stereotyped autonomic responses

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