The immune tissues of the endangered red-tailed phascogale (Phascogale calura)

J. M. Old*, R. L. Carman, G. Fry, E. M. Deane

*Corresponding author for this work

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The lymphoid tissues of the red-tailed phascogale (Phascogale calura) were examined using histological and immunohistochemical techniques. The distribution of immune cells in the tissue beds was documented using antibodies to surface markers CD3 and an MHC Class II antigen (equivalent to HLA DRII). Spleen, gut-associated lymphoid tissues (GALT), lung, bronchus-associated lymphoid tissue (BALT) and liver were examined. The spleen had defined areas of red and white pulp, with follicles containing tingible-bodied macrophages. Anti-CD3 and anti-HLA DRII antibodies revealed the presence of T cells in areas of white pulp and around the peri-arterial lymphatic sheaths. GALT and BALT were detected and appeared as scattered areas of lymphocytes in the tissues beds. This is the first study to report on the lymphoid tissues of this endangered species of marsupial and the first report of the capacity of anti-human antibodies to a surface MHC molecule to react with Dasyurid cells.

Original languageEnglish
Pages (from-to)381-387
Number of pages7
JournalJournal of Anatomy
Volume208
Issue number3
DOIs
Publication statusPublished - Mar 2006

Keywords

  • Dasyurid
  • Endangered species
  • Marsupial
  • Phascogale

Fingerprint Dive into the research topics of 'The immune tissues of the endangered red-tailed phascogale (Phascogale calura)'. Together they form a unique fingerprint.

  • Cite this