The impact of right temporal lobe epilepsy on nonverbal memory: meta-regression of stimulus- and task-related moderators

Adam C. Bentvelzen*, Roy P. C. Kessels, Nicholas A. Badcock, Greg Savage

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    2 Citations (Scopus)

    Abstract

    Nonverbal memory tests have great potential value for detecting the impact of lateralized pathology and predicting the risk of memory loss following right temporal lobe resection (TLR) for temporal lobe epilepsy (TLE) patients, but this potential has not been realized. Previous reviews suggest that stimulus type moderates the capacity of nonverbal memory tests to detect right-lateralized pathology (i.e., faces > designs), but the roles of other task-related factors have not been systematically explored. We address these limitations using mixed model meta-regression (k = 158) of right-lateralization effects (right worse than left TLE) testing the moderating effects of: 1) stimulus type (designs, faces, spatial), 2) learning format (single trial, repeated trials), 3) testing delay (immediate or long delay), and 4) testing format (recall, recognition) for three patient scenarios: 1) presurgical, 2) postsurgical, and 3) postsurgical change. For presurgical patients the size of the right-lateralization effect was significantly moderated by stimulus type (faces > designs), testing format (recall > recognition) and its interaction with the learning format (repeated trials more affected by format effect than single trials) of the nonverbal memory tests. For postsurgical patients and presurgical-postsurgical change, test format moderated the size of the right-lateralization effect (recognition > recall) and this explained and overshadowed effects of stimulus type (i.e., faces > designs). This comprehensive review reveals the value of recognition testing in gauging the risk of nonverbal memory decline.

    Original languageEnglish
    Pages (from-to)537–557
    Number of pages21
    JournalNeuropsychology Review
    Volume32
    Issue number3
    Early online date24 Sep 2021
    DOIs
    Publication statusPublished - Sep 2022

    Bibliographical note

    Correction article can be found at Bentvelzen, A.C., Kessels, R.P.C., Badcock, N.A. et al. Correction to: The Impact of Right Temporal Lobe Epilepsy on Nonverbal Memory: Meta-regression of Stimulus- and Task-related Moderators. Neuropsychol Rev (2022). https://doi.org/10.1007/s11065-022-09545-4

    Keywords

    • temporal lobe epilepsy
    • neuropsychology
    • nonverbal memory
    • meta-analysis
    • lateralization

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