The increased killing of biofilms in vitro by combining topical silver dressings with topical negative pressure in chronic wounds

Pedro Miguel D S Valente, Anand Deva, Quan Ngo, Karen Vickery

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    Chronic wounds remain a significant medical and financial burden in hospitals of today. A major factor in the transition from an acute to a chronic wound is its bacterial bioburden. Developments in molecular techniques have shown that chronic wounds remain colonised by many species of bacteria and that the bacteria within these chronic wounds exist in two forms. Treatments of chronic wounds have maintained a challenging field and significant ongoing research is being conducted. With the development of an in vitro wound model, we applied topical negative pressure (TNP) dressings to a spectrum of common bacterial biofilms found in chronic wounds and studied the synergistic efficacy between the application of TNP and silver-impregnated foam against these biofilms. This synergistic response was seen within the laboratory strains of staphylococcal biofilms over a 3-day treatment period but lost following the 5 days of treatment. However, combining topical pressure dressings and silver foam lead to a synergistic inactivation in Pseudomonas species over both 3-day and 5-day treatments.

    LanguageEnglish
    Pages130-136
    Number of pages7
    JournalInternational Wound Journal
    Volume13
    Issue number1
    DOIs
    Publication statusPublished - 1 Feb 2016

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    Bandages
    Biofilms
    Silver
    Pressure
    Wounds and Injuries
    Negative-Pressure Wound Therapy
    Bacteria
    Therapeutics
    Pseudomonas
    In Vitro Techniques
    Research

    Cite this

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    abstract = "Chronic wounds remain a significant medical and financial burden in hospitals of today. A major factor in the transition from an acute to a chronic wound is its bacterial bioburden. Developments in molecular techniques have shown that chronic wounds remain colonised by many species of bacteria and that the bacteria within these chronic wounds exist in two forms. Treatments of chronic wounds have maintained a challenging field and significant ongoing research is being conducted. With the development of an in vitro wound model, we applied topical negative pressure (TNP) dressings to a spectrum of common bacterial biofilms found in chronic wounds and studied the synergistic efficacy between the application of TNP and silver-impregnated foam against these biofilms. This synergistic response was seen within the laboratory strains of staphylococcal biofilms over a 3-day treatment period but lost following the 5 days of treatment. However, combining topical pressure dressings and silver foam lead to a synergistic inactivation in Pseudomonas species over both 3-day and 5-day treatments.",
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    The increased killing of biofilms in vitro by combining topical silver dressings with topical negative pressure in chronic wounds. / Valente, Pedro Miguel D S; Deva, Anand; Ngo, Quan; Vickery, Karen.

    In: International Wound Journal, Vol. 13, No. 1, 01.02.2016, p. 130-136.

    Research output: Contribution to journalArticleResearchpeer-review

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