The integration of pharmacology and pathophysiology into locoregional chemotherapy delivery via mass fluid transfer

R. J. Lane, N. Y. Khin, C. M. Rogan, J. S. Magnussen, K. Ho-Shon, N. Pavlakis, S. J. Clarke, T. J. Hugh

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The prevailing paradigm of locoregional chemotherapy has been centred around delivering chemotherapy as close to the tumour as possible and in some cases incorporating vascular isolation techniques. Strategically, the development of these techniques has been rudimentary without consideration for the interdependencies between macrovascular manipulation and the microvascular effects. This review focuses on how new capabilities offered by recent advances in vascular access technology could be exploited to facilitate the mass fluid transfer (MFT) of anticancer agents to solid tumours. A haemodynamic model of MFT is proposed using the physical laws of fluid flow, flux, and diffusion that describe the microvascular effects anticancer agents may have upon tumours through the manipulation of macrovascular blood flow control. Finally, the possible applications of this technique for several organs are discussed.

LanguageEnglish
Pages18-28
Number of pages11
JournalJournal of Controlled Release
Volume292
Early online date19 Oct 2018
DOIs
Publication statusPublished - 28 Dec 2018

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Pharmacology
Drug Therapy
Antineoplastic Agents
Blood Vessels
Neoplasms
Hemodynamics
Technology

Cite this

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title = "The integration of pharmacology and pathophysiology into locoregional chemotherapy delivery via mass fluid transfer",
abstract = "The prevailing paradigm of locoregional chemotherapy has been centred around delivering chemotherapy as close to the tumour as possible and in some cases incorporating vascular isolation techniques. Strategically, the development of these techniques has been rudimentary without consideration for the interdependencies between macrovascular manipulation and the microvascular effects. This review focuses on how new capabilities offered by recent advances in vascular access technology could be exploited to facilitate the mass fluid transfer (MFT) of anticancer agents to solid tumours. A haemodynamic model of MFT is proposed using the physical laws of fluid flow, flux, and diffusion that describe the microvascular effects anticancer agents may have upon tumours through the manipulation of macrovascular blood flow control. Finally, the possible applications of this technique for several organs are discussed.",
author = "Lane, {R. J.} and Khin, {N. Y.} and Rogan, {C. M.} and Magnussen, {J. S.} and K. Ho-Shon and N. Pavlakis and Clarke, {S. J.} and Hugh, {T. J.}",
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The integration of pharmacology and pathophysiology into locoregional chemotherapy delivery via mass fluid transfer. / Lane, R. J.; Khin, N. Y.; Rogan, C. M.; Magnussen, J. S.; Ho-Shon, K.; Pavlakis, N.; Clarke, S. J.; Hugh, T. J.

In: Journal of Controlled Release, Vol. 292, 28.12.2018, p. 18-28.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Lane, R. J.

AU - Khin, N. Y.

AU - Rogan, C. M.

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AU - Ho-Shon, K.

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AU - Clarke, S. J.

AU - Hugh, T. J.

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