TY - JOUR
T1 - The interpretation of powder compaction data - a critical review
AU - Krycer, Ian
AU - Pope, David G.
AU - Hersey, John A.
PY - 1982
Y1 - 1982
N2 - Some of the most common methods of interpreting powder compaction data are described. These include compaction energy versus tablet hardness profiles, Heckel plots, stress relaxation and elastic recovery measurements and radial versus axial pressure cycles. By comparing and critically evaluating the techniques employed and results obtained by independent studies, it is shown that considerable confusion exists in the literature. As well, it is demonstrated that in numerous studies, further substantiation of the techniques employed is required. As a guide for future research, some of the most useful and possibly least ambiguous methods of interpreting compaction data are recommended.
AB - Some of the most common methods of interpreting powder compaction data are described. These include compaction energy versus tablet hardness profiles, Heckel plots, stress relaxation and elastic recovery measurements and radial versus axial pressure cycles. By comparing and critically evaluating the techniques employed and results obtained by independent studies, it is shown that considerable confusion exists in the literature. As well, it is demonstrated that in numerous studies, further substantiation of the techniques employed is required. As a guide for future research, some of the most useful and possibly least ambiguous methods of interpreting compaction data are recommended.
UR - http://www.scopus.com/inward/record.url?scp=0000858707&partnerID=8YFLogxK
U2 - 10.3109/03639048209022103
DO - 10.3109/03639048209022103
M3 - Article
AN - SCOPUS:0000858707
SN - 0363-9045
VL - 8
SP - 307
EP - 342
JO - Drug Development and Industrial Pharmacy
JF - Drug Development and Industrial Pharmacy
IS - 3
ER -