The interpretation of powder compaction data - a critical review

Ian Krycer*, David G. Pope, John A. Hersey

*Corresponding author for this work

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Some of the most common methods of interpreting powder compaction data are described. These include compaction energy versus tablet hardness profiles, Heckel plots, stress relaxation and elastic recovery measurements and radial versus axial pressure cycles. By comparing and critically evaluating the techniques employed and results obtained by independent studies, it is shown that considerable confusion exists in the literature. As well, it is demonstrated that in numerous studies, further substantiation of the techniques employed is required. As a guide for future research, some of the most useful and possibly least ambiguous methods of interpreting compaction data are recommended.

Original languageEnglish
Pages (from-to)307-342
Number of pages36
JournalDrug Development and Industrial Pharmacy
Volume8
Issue number3
DOIs
Publication statusPublished - 1982
Externally publishedYes

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