The involvement of lipids in Alzheimer's disease

Wei Ling Florence Lim, Ian James Martins, Ralph Nigel Martins*

*Corresponding author for this work

Research output: Contribution to journalReview article

37 Citations (Scopus)

Abstract

It has been estimated that Alzheimer's disease (AD), the most common form of dementia, will affect approximately 81 million individuals by 2040. To date, the actual cause and cascade of events in the progression of this disease have not been fully determined. Furthermore, there is currently no definitive blood test or simple diagnostic method for AD. Considerable efforts have been put into proteomic approaches to develop a diagnostic blood test, but to date these efforts have not been successful. More recently, there has been a stronger focus on lipidomic studies in the hope of increasing our understanding of the underlying mechanisms leading to AD and developing an AD blood test. It is well known that the strongest genetic risk factor for AD is the ε4 variant of apolipoprotein E (APOE). Evidence suggests that the ApoE protein, a major lipid transporter, plays a key role in the pathogenesis of AD, and its role in both normal and aberrant lipid metabolism warrants further extensive investigation. Here, we review ApoE-lipid interactions, as well as the roles that lipids may play in the pathogenesis of AD.

Original languageEnglish
Pages (from-to)261-274
Number of pages14
JournalJournal of Genetics and Genomics
Volume41
Issue number5
DOIs
Publication statusPublished - 20 May 2014
Externally publishedYes

Keywords

  • Alzheimer's disease
  • ApoE
  • Inflammation
  • Lipids
  • Oxysterols

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