The kynurenine pathway in stem cell biology

Simon P. Jones*, Gilles J. Guillemin, Bruce J. Brew

*Corresponding author for this work

    Research output: Contribution to journalReview article

    28 Citations (Scopus)
    12 Downloads (Pure)

    Abstract

    The kynurenine pathway (KP) is the main catabolic pathway of the essential amino acid tryptophan. The KP has been identified to play a critical role in regulating immune responses in a variety of experimental settings. It is also known to be involved in several neuroinflammatory diseases including Huntington's disease, amyotrophic lateral sclerosis, and Alzheimer's disease. This review considers the current understanding of the role of the KP in stem cell biology. Both of these fundamental areas of cell biology have independently been the focus of a burgeoning research interest in recent years. A systematic review of how the two interact has not yet been conducted. Several inflammatory and infectious diseases in which the KP has been implicated include those for which stem cell therapies are being actively explored at a clinical level. Therefore, it is highly relevant to consider the evidence showing that the KP influences stem cell biology and impacts the functional behavior of progenitor cells.

    Original languageEnglish
    Pages (from-to)57-66
    Number of pages10
    JournalInternational Journal of Tryptophan Research
    Volume6
    DOIs
    Publication statusPublished - 2013

    Bibliographical note

    Copyright the Author(s) 2013. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

    Keywords

    • 3-dioxygenase
    • Embryonic stem cell
    • Haematopoietic stem cell
    • Indoleamine 2
    • kynurenine pathway
    • Mesenchymal stem cell
    • Neural stem cell
    • Tryptophan

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