The mechanisms underlying fructose-induced hypertension: A review

Alice Victoria Klein, Hosen Kiat*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

68 Citations (Scopus)
37 Downloads (Pure)

Abstract

We are currently in the midst of an epidemic of metabolic disorders, which may, in part, be explained by excess fructose intake. This theory is supported by epidemiological observations as well as experimental studies in animals and humans. Rising consumption of fructose has been matched with growing rates of hypertension, leading to concern from public health experts. At this stage, the mechanisms underlying fructose-induced hypertension have not been fully characterized and the bulk of our knowledge is derived from animal models. Animal studies have shown that high-fructose diets up-regulate sodium and chloride transporters, resulting in a state of salt overload that increases blood pressure. Excess fructose has also been found to activate vasoconstrictors, inactivate vasodilators, and over-stimulate the sympathetic nervous system. Further work is required to determine the relevance of these findings to humans and to establish the level at which dietary fructose increases the risk of developing hypertension.

Original languageEnglish
Pages (from-to)912-920
Number of pages9
JournalJournal of Hypertension
Volume33
Issue number5
DOIs
Publication statusPublished - 11 May 2015

Bibliographical note

Copyright the Publisher 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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