The morphology of allograft rejection in Styela plicata (Urochordata: Ascidiacea)

David A. Raftos*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

This study identifies three discrete processes responsible for the rejection of tunic tissue transplanted between individuals of the solitary ascidian Styela plicata. The first stage of rejection is characterized by the destruction of blood vascular components within incompatible allografts. In the second phase, dense boundaries of extracellular material are deposited between grafts and the surrounding host tunic, effectively amputating the transplanted tissues. Finally, detached transplants undergo a gradual necrosis which results in the total degeneration of extracellular graft matrices. Of these three phases, the initial cellular depletion of allografts is responsible for the immunological specificity that is characteristic of histocompatibility in S. plicata. The subsequent amputation and necrosis of extracellular graft matrices are taken to be non-specific consequences of the initial cellular reactivity.

Original languageEnglish
Pages (from-to)389-396
Number of pages8
JournalCell and Tissue Research
Volume261
Issue number2
DOIs
Publication statusPublished - Aug 1990
Externally publishedYes

Keywords

  • Graft rejection
  • Histocompatibility
  • Styela plicata (Tunicata)
  • Transplantation

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