The nanoscale in pulmonary delivery. Part 2: formulation platforms

Philippe G. A. Rogueda*, Daniela Traini

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

47 Citations (Scopus)

Abstract

This article is the second part of a review on the nanoscale in pulmonary drug delivery. Specifically it summarises and analyses the potential of the different inhalation delivery routes: nebulisers, dry powder inhalers, pressurised metered-dose inhalers, for the delivery of nanoparticles or nanodroplets. Few products and experimental studies have managed to fully exploit the nanoscale in inhalation delivery, although some may unknowingly benefit from it. Nebulisers are the most advanced in using the nanoscale, pressurised metered-dose inhalers require further developments to realise its full potential, and dry powder inhalers are specifically in need of a dry solid nanoparticle generation technique to make it a reality.

Original languageEnglish
Pages (from-to)607-620
Number of pages14
JournalExpert Opinion on Drug Delivery
Volume4
Issue number6
DOIs
Publication statusPublished - Nov 2007
Externally publishedYes

Keywords

  • Drug delivery
  • Dry powder inhaler
  • Formulation
  • Inhalation
  • Nano
  • Nanodroplet
  • Nanoparticle
  • Nanoscale
  • Nebuliser
  • Pressurized metered-dose inhaler
  • Pulmonary delivery

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