The nature of myocardial heart failure: are hypertrophic cardiomyopathies all the same?

Amy Li; Dane King; Martijn Bos; Eleanor Kable; Peter Macdonald; Filip Braet; Brett Hambly; Shin'ichi Ishiwata; Michael Ackerman; Murat Kekic

doi:10.2142/biophys.53.S99_4

The nature of myocardial heart failure: are hypertrophic cardiomyopathies all the same?

Amy Li, Dane King, Martijn Bos, Eleanor Kable, Peter Macdonald, Filip Braet, Brett Hambly, Shin'ichi Ishiwata, Michael Ackerman, Murat Kekic

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution

Abstract

Hypertrophic cardiomyopathy (HCM) has an incidence of 1:500 with at least 40% of this population directly caused by sarcomeric gene mutations. In this study we examine two of the most frequently mutated contractile proteins in HCM patients; MYBPC3 and the troponin family (Tn). SPontaneous Oscillatory Contractions (SPOCs) were induced in myectomy samples to identify functional characteristics of these mutations in the contraction-relaxation cycles that are intrinsic to the sarcomeres. PCA demonstrated distinctive clustering of the two HCM mutant myectomy populations and donors. However, we found no differences between the types of mutations and their pathological variants. This information will help us to understand the underlying mechanics of the failing HCM phenotype.

Original language	English
Title of host publication	ASB-BSJ Bilateral Symposium 2013
Subtitle of host publication	The 51th Annual Meeting of the Biophysical Society of Japan
Publisher	Biophysical Society of Japan
Pages	S99
Number of pages	1
Volume	53, Supplement 1-2
ISBN (Electronic)	1347-4219
ISBN (Print)	0582-4052
DOIs	https://doi.org/10.2142/biophys.53.S99_4
Publication status	Published - 2013
Externally published	Yes
Event	Annual Meeting of the Biophysical Society of Japan (51st : 2013) - Kyoto International Conference Centre, Kyoto, Japan Duration: 28 Oct 2013 → 30 Oct 2013

Conference

Conference	Annual Meeting of the Biophysical Society of Japan (51st : 2013)
Abbreviated title	BSJ51
Country	Japan
City	Kyoto
Period	28/10/13 → 30/10/13

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10.2142/biophys.53.S99_4

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Li, A., King, D., Bos, M., Kable, E., Macdonald, P., Braet, F., Hambly, B., Ishiwata, S., Ackerman, M., & Kekic, M. (2013). The nature of myocardial heart failure: are hypertrophic cardiomyopathies all the same? In ASB-BSJ Bilateral Symposium 2013: The 51th Annual Meeting of the Biophysical Society of Japan (Vol. 53, Supplement 1-2, pp. S99). Biophysical Society of Japan. https://doi.org/10.2142/biophys.53.S99_4

Li, Amy ; King, Dane ; Bos, Martijn ; Kable, Eleanor ; Macdonald, Peter ; Braet, Filip ; Hambly, Brett ; Ishiwata, Shin'ichi ; Ackerman, Michael ; Kekic, Murat. / The nature of myocardial heart failure : are hypertrophic cardiomyopathies all the same?. ASB-BSJ Bilateral Symposium 2013: The 51th Annual Meeting of the Biophysical Society of Japan. Vol. 53, Supplement 1-2 Biophysical Society of Japan, 2013. pp. S99

@inproceedings{870d20d7e91f4412af0f644bbbc0d7f4,

title = "The nature of myocardial heart failure: are hypertrophic cardiomyopathies all the same?",

abstract = "Hypertrophic cardiomyopathy (HCM) has an incidence of 1:500 with at least 40% of this population directly caused by sarcomeric gene mutations. In this study we examine two of the most frequently mutated contractile proteins in HCM patients; MYBPC3 and the troponin family (Tn). SPontaneous Oscillatory Contractions (SPOCs) were induced in myectomy samples to identify functional characteristics of these mutations in the contraction-relaxation cycles that are intrinsic to the sarcomeres. PCA demonstrated distinctive clustering of the two HCM mutant myectomy populations and donors. However, we found no differences between the types of mutations and their pathological variants. This information will help us to understand the underlying mechanics of the failing HCM phenotype.",

author = "Amy Li and Dane King and Martijn Bos and Eleanor Kable and Peter Macdonald and Filip Braet and Brett Hambly and Shin'ichi Ishiwata and Michael Ackerman and Murat Kekic",

year = "2013",

doi = "10.2142/biophys.53.S99_4",

language = "English",

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pages = "S99",

booktitle = "ASB-BSJ Bilateral Symposium 2013",

publisher = "Biophysical Society of Japan",

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note = "Annual Meeting of the Biophysical Society of Japan (51st : 2013), BSJ51 ; Conference date: 28-10-2013 Through 30-10-2013",

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Li, A, King, D, Bos, M, Kable, E, Macdonald, P, Braet, F, Hambly, B, Ishiwata, S, Ackerman, M & Kekic, M 2013, The nature of myocardial heart failure: are hypertrophic cardiomyopathies all the same? in ASB-BSJ Bilateral Symposium 2013: The 51th Annual Meeting of the Biophysical Society of Japan. vol. 53, Supplement 1-2, Biophysical Society of Japan, pp. S99, Annual Meeting of the Biophysical Society of Japan (51st : 2013), Kyoto, Japan, 28/10/13. https://doi.org/10.2142/biophys.53.S99_4

The nature of myocardial heart failure : are hypertrophic cardiomyopathies all the same? / Li, Amy; King, Dane; Bos, Martijn; Kable, Eleanor; Macdonald, Peter; Braet, Filip; Hambly, Brett; Ishiwata, Shin'ichi; Ackerman, Michael; Kekic, Murat.

ASB-BSJ Bilateral Symposium 2013: The 51th Annual Meeting of the Biophysical Society of Japan. Vol. 53, Supplement 1-2 Biophysical Society of Japan, 2013. p. S99.

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution

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AU - Li, Amy

AU - King, Dane

AU - Bos, Martijn

AU - Kable, Eleanor

AU - Macdonald, Peter

AU - Braet, Filip

AU - Hambly, Brett

AU - Ishiwata, Shin'ichi

AU - Ackerman, Michael

AU - Kekic, Murat

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N2 - Hypertrophic cardiomyopathy (HCM) has an incidence of 1:500 with at least 40% of this population directly caused by sarcomeric gene mutations. In this study we examine two of the most frequently mutated contractile proteins in HCM patients; MYBPC3 and the troponin family (Tn). SPontaneous Oscillatory Contractions (SPOCs) were induced in myectomy samples to identify functional characteristics of these mutations in the contraction-relaxation cycles that are intrinsic to the sarcomeres. PCA demonstrated distinctive clustering of the two HCM mutant myectomy populations and donors. However, we found no differences between the types of mutations and their pathological variants. This information will help us to understand the underlying mechanics of the failing HCM phenotype.

AB - Hypertrophic cardiomyopathy (HCM) has an incidence of 1:500 with at least 40% of this population directly caused by sarcomeric gene mutations. In this study we examine two of the most frequently mutated contractile proteins in HCM patients; MYBPC3 and the troponin family (Tn). SPontaneous Oscillatory Contractions (SPOCs) were induced in myectomy samples to identify functional characteristics of these mutations in the contraction-relaxation cycles that are intrinsic to the sarcomeres. PCA demonstrated distinctive clustering of the two HCM mutant myectomy populations and donors. However, we found no differences between the types of mutations and their pathological variants. This information will help us to understand the underlying mechanics of the failing HCM phenotype.

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M3 - Conference proceeding contribution

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