The nature of myocardial heart failure: are hypertrophic cardiomyopathies all the same?

Amy Li, Dane King, Martijn Bos, Eleanor Kable, Peter Macdonald, Filip Braet, Brett Hambly, Shin'ichi Ishiwata, Michael Ackerman, Murat Kekic

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contribution

Abstract

Hypertrophic cardiomyopathy (HCM) has an incidence of 1:500 with at least 40% of this population directly caused by sarcomeric gene mutations. In this study we examine two of the most frequently mutated contractile proteins in HCM patients; MYBPC3 and the troponin family (Tn). SPontaneous Oscillatory Contractions (SPOCs) were induced in myectomy samples to identify functional characteristics of these mutations in the contraction-relaxation cycles that are intrinsic to the sarcomeres. PCA demonstrated distinctive clustering of the two HCM mutant myectomy populations and donors. However, we found no differences between the types of mutations and their pathological variants. This information will help us to understand the underlying mechanics of the failing HCM phenotype.
Original languageEnglish
Title of host publicationASB-BSJ Bilateral Symposium 2013
Subtitle of host publicationThe 51th Annual Meeting of the Biophysical Society of Japan
PublisherBiophysical Society of Japan
PagesS99
Number of pages1
Volume53, Supplement 1-2
ISBN (Electronic)1347-4219
ISBN (Print)0582-4052
DOIs
Publication statusPublished - 2013
Externally publishedYes
EventAnnual Meeting of the Biophysical Society of Japan (51st : 2013) - Kyoto International Conference Centre, Kyoto, Japan
Duration: 28 Oct 201330 Oct 2013

Conference

ConferenceAnnual Meeting of the Biophysical Society of Japan (51st : 2013)
Abbreviated titleBSJ51
CountryJapan
CityKyoto
Period28/10/1330/10/13

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