The neuropsychological and language profile of children with benign rolandic epilepsy

Ellen Northcott, Anne M. Connolly, Anna Berroya, Mark Sabaz, Jenny McIntyre, Jane Christie, Alan Taylor, Jennifer Batchelor, Andrew F. Bleasel, John A. Lawson, Ann M E Bye*

*Corresponding author for this work

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113 Citations (Scopus)

Abstract

Purpose: Benign rolandic epilepsy (BRE) has an excellent prognosis for seizures, but recent research has raised concerns using cognition as an outcome measure. Methodologic problems related to recruitment bias and assessment processes are evident in previous studies. With well-defined criteria for inclusion and comprehensive assessment, the aim of this study was to define the cognitive profile of children with BRE and to assess the effect of interictal EEG activity. Methods: Patients (n = 42) were recruited from six EEG laboratories. The EEG features analyzed were spike frequency, trains, and laterality. Comprehensive neuropsychological and language assessments were conducted. Group means on cognitive measures were compared with normative means. Tests were correlated with EEG features. Results: The study demonstrated that children with BRE have normal intelligence and language ability. However, a specific pattern of difficulties in memory and phonologic awareness was found. Furthermore, a large proportion of children had disproportionate scores in these areas compared with intellectual and language ability. EEG features were minimally associated with cognitive difficulties, and no correlation was found with memory indices and tests of phonologic awareness. Conclusions: Some children with BRE have specific difficulties in memory and phonologic processing skills, not explained by interictal activity. We recommend that pediatricians ask about academic performance specifically in areas of pre-reading, reading, spelling, and memory. If difficulties are suspected, assessment targeting phonologic awareness and memory are recommended, as they may not be reflected in overall intellectual and language ability. Difficulties in phonologic awareness affect literacy, and memory problems affect academic performance.

Original languageEnglish
Pages (from-to)924-930
Number of pages7
JournalEpilepsia
Volume46
Issue number6
DOIs
Publication statusPublished - Jun 2005

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Northcott, E., Connolly, A. M., Berroya, A., Sabaz, M., McIntyre, J., Christie, J., ... Bye, A. M. E. (2005). The neuropsychological and language profile of children with benign rolandic epilepsy. Epilepsia, 46(6), 924-930. https://doi.org/10.1111/j.1528-1167.2005.62304.x